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Gamma Interferon Release Assay for Monitoring of Treatment Response for Active Tuberculosis: an Explosion in the Spaghetti Factory |
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| Authors: | Claudia M. Denkinger Madhukar Pai Meena Patel Dick Menzies |
| Affiliation: | aDepartment of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA;bDepartment of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Quebec, Canada;cRespiratory Epidemiology & Clinical Research Unit, Montreal Chest Institute, Montreal, Quebec, Canada |
| Abstract: | Few studies have correlated the results of interferon (gamma interferon) release assays (IGRAs) with known markers of tuberculosis (TB) treatment response. We report the results of serial QuantiFERON-TB gold in-tube assay (QFT) testing on 149 patients with active tuberculosis and correlate the results with smear and culture conversion. We show that QFT results do not offer much value for treatment monitoring of TB disease. |
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