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TCA cycle metabolic compromise due to an aberrant S-nitrosoproteome in HIV-associated neurocognitive disorder with methamphetamine use |
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| Authors: | Doulias Paschalis-Thomas Nakamura Tomohiro Scott Henry McKercher Scott R. Sultan Abdullah Deal Amanda Albertolle Matthew Ischiropoulos Harry Lipton Stuart A. |
| Affiliation: | 1.Children’s Hospital of Philadelphia Research Institute and Departments of Pediatrics and Pharmacology, Raymond and Ruth Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA ;2.Department of Chemistry, University of Ioannina, 45110, Ioannina, Greece ;3.Department of Molecular Medicine and Neurodegeneration New Medicines Center, The Scripps Research Institute, La Jolla, San Diego, CA, 92037, USA ;4.Department of Neurosciences, School of Medicine, University of California, San Diego, La Jolla, San Diego, CA, 92093, USA ; |
| Abstract: | Journal of NeuroVirology - In the brain, both HIV-1 and methamphetamine (meth) use result in increases in oxidative and nitrosative stress. This redox stress is thought to contribute to the... |
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