基于分子表型的脑胶质瘤影像基因组学研究进展

影像基因组学是一个新兴研究领域,它通过整合疾病影像特征和基因表达,于两者间构建一定的相关性,是目前医学科研最有前景的研究领域之一。脑胶质瘤由病理学诊断向分子诊断的深入,对胶质瘤预后的评估越来越依赖基因表达特征或分子表型,而运用影像基因组学方法,通过利用影像数据预测分子表达特征可以无创地预测胶质瘤的预后,同时为实现胶质瘤的精准诊断和精准治疗提供一种重要工具,近年已成为影像基因组学研究的热点之一。就脑胶质瘤的影像基因组学研究进展予以综述。

Research progress of radiogenomics and imaging phenotypes in glioma

Radiogenomics is an emerging research field. It integrates imaging features and gene expression of disease, building a certain correlation between them, and is one of the most promising research fields in medical research. The prognosis assessment of glioma is increasingly depended on gene expression profiles or molecular phenotype, when glioma diagnosis shifts from pathological to molecular diagnosis. By using radiogenomic method to predict molecular expression profiles with image data, prognosis of glioma can be predicted non-invasively. Radiogenomics of glioma as an important tool for achieving accurate diagnosis and precise treatment has become one of radiogenomic research focus in recent years. In this paper, the radiogenomics research progresses in glioma were reviewed.