Ki67在乳腺癌组织中的表达及其临床意义研究

目的探讨乳腺癌组织Ki67表达水平及其与疾病分型、患者预后等的相关性。方法收集2013年1月至2015年12月于本院治疗的93例乳腺癌患者及20例乳腺良性疾病患者临床资料,分析Ki67指数与疾病病理参数及实验室指标的相关性。结果 93例乳腺癌患者Ki67指数水平为1%~90%,中位数为21.65%。乳腺癌组织学分级、肿瘤直径、人表皮生长因子受体2(HER2)表达状态与Ki67指数相关(P0.05),年龄、绝经状态、肿瘤TNM分期、腋窝淋巴结转移状态、雌激素受体(ER)及孕激素受体(PR)表达状态与Ki67指数无关(P0.05)。三阴性乳腺癌、非三阴性乳腺癌及乳腺良性疾病患者Ki67指数中位数依次为30.15%、20.26%、4.67%,三者间Ki67指数比较差异有统计学意义(P0.05)。Ki67指数水平与乳腺癌分型相关(P0.05),与患者血细胞比容和血钾浓度水平相关(P0.05)。结论 Ki67指数联合其他指标可用于乳腺癌诊治及患者预后判断,具有一定的临床应用价值。

Expression of Ki67 and clinical significance in breast cancer

Objective To explore the expression level of Ki67 and its correlation with clinicopathological types and prognosis of patients with breast cancer.Methods Clinical data of 93 patients with breast cancer and 20 patients with benign breast diseases were collected from Jan.2013 to Dec.2015,and the correlation between Ki67 and pathological parameters and laboratory parameters were analyzed.Results Among the 93 patients with breast cancer,the Ki67 index was 1% to 90%,with median of 21.65%.Ki67 index was correlated with tumor grade,tumor size and human epidermalgrowth factor receptor-2(HER2,P<0.05).However,Ki67 index was without correlation with age,menopausal status,tumor TNM stage,lymph node metastasis,estrogen receptor(ER) and progesterone receptor(PR,P>0.05).Ki67 index of patients with triple negative breast cancer,patients with non-triple negative breast cancer and patients with benign breast diseases were 30.15%,20.26% and 4.67%,which were with significant difference(P<0.04).Ki67 index was also related to the breast cancer subtypes(P<0.05),and serum potassium and hematocrit levels of patients with breast cancer(P<0.05).Conclusion Ki67 index could be used for the diagnosis,treatment and prognosis of patients with breast cancer.