| 马钱子碱聚乳酸载药纳米粒的制备和体外评价 |
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| 引用本文： | 赵继会,刘召林,许洁,于燕燕,冯年平.马钱子碱聚乳酸载药纳米粒的制备和体外评价[J].中国中药杂志,2009,34(18):2322-2324. |
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| 作者姓名： | 赵继会 刘召林 许洁 于燕燕 冯年平 |
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| 作者单位： | 上海中医药大学,药剂教研室,上海,201203 |
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| 基金项目： | 上海市博士点基金(2006B02)；上海市教委项目(07ZZ53)；上海市教委重点学科项目(J50302) |
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| 摘 要： | 目的:制备和评价马钱子碱聚乳酸载药纳米粒(Bru-PLA-NPs).方法:采用溶剂扩散法制备Bru-PLA-NPs,并对其进行表征和体外释药评价.结果:制得的Bru-PLA-NPs的平均粒径为95 nm,多分散指数为0.362,zeta电位为-15.68 mV.Bru的平均载药量和包封率分别为7%,37%.体外释药试验表明,与Bru溶液相比Bru-PLA-NPs具有明显的缓释作用.结论:采用溶剂扩散法制备的Bru-PLA-NPs粒径小,载药量高,具有明显的缓释作用.
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| 关 键 词： | 马钱子碱 聚乳酸纳米粒 体外释放 |
| 收稿时间： | 2009/1/16 0:00:00 |
Preparation and in vitro evaluation of brucine-loaded Polylacticacid Nanoparticles |
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| ZHAO Jihui,LIU Zhaolin,XU Jie,YU Yanyan and FENG Nianping.Preparation and in vitro evaluation of brucine-loaded Polylacticacid Nanoparticles[J].China Journal of Chinese Materia Medica,2009,34(18):2322-2324. |
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| Authors: | ZHAO Jihui LIU Zhaolin XU Jie YU Yanyan and FENG Nianping |
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| Abstract: | Objective: To prepare and evaluate brucine-loaded polylacticacid nanoparticles (Bru-PLA-NPs). Method: The Bru-PLA-NPs were prepared by solvent diffusion method. The physical, chemical properties and in vitro release behavior of the prepared Bru-PLA-NPs were evaluated, respectively. Result: The mean particle size of the prepared Bru-PLA-NPs was 95 nm with polydispersity index of 0.362. The zeta potential was -15.68 mV. The mean loading and entrapment efficiency of Bru were 7% and 37%, respectively. Compared with Bru solution, an obvious sustained release behavior of Bru from Bru-PLA-NPs was observed in the in vitro release experiment. Conclusion: The Bru-PLA-NPs prepared by solvent diffusion method exhibit small particle size, high Bru-loading efficiency, and obvious sustained release in vitro |
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| Keywords: | brucine PLA nanoparticles in vitro release |
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