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| 中药黄斑明目胶囊防治N-甲基-N-亚硝脲诱导大鼠视网膜变性的早期效应 | |
| 引用本文： | 王延东,甄栋钦,姚向超,唐细兰,叶成添. 中药黄斑明目胶囊防治N-甲基-N-亚硝脲诱导大鼠视网膜变性的早期效应[J]. 中国临床药学杂志, 2011, 0(1): 8-12 |
| 作者姓名： | 王延东 甄栋钦 姚向超 唐细兰 叶成添 |
| 作者单位： | 中山大学中山眼科中心药剂科; |
| 基金项目： | 广东省中医药管理局科研项目(编号2009165) |
| 摘 要： | 目的观察中药黄斑明目胶囊对N-甲基-N-亚硝脲（MNU）诱导大鼠视网膜变性的早期拮抗效应。方法将鼠龄为43 d的♀SD大鼠30只随机分为3组,每组10只。黄斑明目胶囊组以中药黄斑明目胶囊溶解后灌胃,正常对照组和模型对照组以等量蒸馏水灌胃,bid,连续7 d。给药7d后,黄斑明目胶囊组和模型对照组大鼠予MNU 40 mg·kg-1,ip;正常对照组注射等量生理盐水。观察MNU处理后12、24、48、72 h各组大鼠视网膜电图（ERG）a波及b波的变化,并于MNU处理后7 d处死大鼠,取眼球做组织学观察。结果正常对照组大鼠不同时间点ERG a波及b波的振幅差异无统计学意义;模型对照组在MNU处理后ERG a波及b波的振幅均呈持续性、进行性下降;中药黄斑明目胶囊可明显抑制ERG a波及b波振幅的降低。通过透视电子显微镜和光学显微镜对视网膜的组织学观察显示,中药黄斑明目胶囊组的病理组织学损害较模型对照组明显减轻。结论中药黄斑明目胶囊可拮抗MNU诱导的视网膜变性大鼠的早期损伤。 |
| 关 键 词： | 黄斑明目胶囊 视网膜变性 N-甲基-N-亚硝脲 拮抗效应 |
Early effects of Huangbanmingmu capsule on retinal degeneration in rats induced by N-methyl-N-nitrosourea |
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| WANG Y,ong,ZHEN Dongqin,YAO Xiangchao,TANG Xilan,YE Chengtian. Early effects of Huangbanmingmu capsule on retinal degeneration in rats induced by N-methyl-N-nitrosourea[J]. Chinese Journal of Clinical Pharmacy, 2011, 0(1): 8-12 | |
| Authors: | WANG Y ong ZHEN Dongqin YAO Xiangchao TANG Xilan YE Chengtian |
| Affiliation: | WANG Yandong,ZHEN Dongqin,YAO Xiangchao,TANG Xilan,YE Chengtian(Department of Pharmacy,Zhongshan Ophthalmic Center,Sun Yat-sen University,Guangzhou 510060,China) |
| Abstract: | AIM To observe the early antagonistic effects of Huangbanmingmu capsule on retinal degeneration induced by N-methyl-N-nitrosourea(MNU) in SD rats.METHODS Female SD rats of 43-day-old were randomly divided into control group,model control group and Huangbanmingmu capsule group.Huangbanmingmu capsule was irrigated into rats with intragastric administration in Huangbanmingmu capsule group for continuous 7 d twice one day.Control group and model group were given equal distilled water.SD rats in 7 d after treatm... |
| Keywords: | Huangbanmingmu capsule retinal degeneration N-methyl-N-nitrosourea antagonistic effect |
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