| 抗凝专业药师参与1例华法林抵抗的肺栓塞患者用药方案制订 |
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| 引用本文： | 丁征,洪珊珊,张进华.抗凝专业药师参与1例华法林抵抗的肺栓塞患者用药方案制订[J].中国药师,2016(2):322-324. |
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| 作者姓名： | 丁征 洪珊珊 张进华 |
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| 作者单位： | 1.福建医科大学附属协和医院抗凝药物治疗专业临床药师培训基地 福州 350001；2.中国医学科学院阜外医院药剂科；3.福建省泉州市第一医院药剂科 |
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| 基金项目： | 留学回国人员科研启动项目（编号：2015B001） |
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| 摘 要： | 摘 要 目的： 抗凝专业的临床药师参与制订华法林抵抗患者治疗方案。 方法: 针对1例华法林抵抗的肺栓塞患者进行原因分析，提供华法林用药方案。结果: 该华法林抵抗患者通过基因检测明确基因型为VKORC1 1639AG型，排除其他原因，确定为遗传性华法林抵抗，药师协助制订了用药方案，使患者INR值达标。结论:针对华法林抵抗的患者，首先明确华法林抵抗的原因，制定相应的治疗策略，基因检测对于华法林抵抗的患者不失为一种重要手段。
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| 关 键 词： | 肺栓塞 华法林抵抗 抗凝 临床药师 |
| 收稿时间： | 2015/6/19 0:00:00 |
| 修稿时间： | 2015/11/2 0:00:00 |
Participation of Anticoagulant Professional Pharmacist in the Medication for a Pulmonary Embolism Patient with Warfarin Resistance |
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| Ding Zheng,Hong Shanshan,Zhang Jinhua.Participation of Anticoagulant Professional Pharmacist in the Medication for a Pulmonary Embolism Patient with Warfarin Resistance[J].China Pharmacist,2016(2):322-324. |
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| Authors: | Ding Zheng Hong Shanshan Zhang Jinhua |
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| Institution: | 1.Aanti coagulant Therapy Major, Training Center of Clinical Pharmacy, Fujian Medical University Union Hospital, Fuzhou 350001, China; 2.Department of Pharmacy, Fuwai Hospital Chinese Academy of Medical Sciences; 3.Department of Pharmacy, Quanzhou First Hospital |
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| Abstract: | ABSTRACT Objective: To discuss the therapeutic regimen for warfarin resistant patients with the help of clinical pharmacists. Methods: The pharmacist analyzed the cause of warfarin resistance and provided the dose adjustment for a pulmonary embolism patient. Results: The genotype of the patient was identified as VKORC1 1639AG by gene test. The patient was diagnosed as hereditary warfarin resistance excluding other causes. With the assistance of pharmacist, the problem of warfarin resistant was solved. Conclusion:For warfarin resistant patients, clinical pharmacists must definite the reason of warfarin resistant firstly and then carry out the therapeutic strategy. Gene detection may be used as an important guide for warfarin resistance. |
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| Keywords: | Pulmonary embolism Warfarin resistance Anticoagulant Clinical pharmacist |
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