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| 复方磷酸可待因片镇痛效果的多中心临床评价 | |
| 引用本文： | 沈黎阳,徐国柱,刘丽京,俞立英,陈清棠,郝中顺,王杰军,曹斌融,朱天岳. 复方磷酸可待因片镇痛效果的多中心临床评价[J]. 中国药物依赖性杂志, 2003, 12(1): 34-39 |
| 作者姓名： | 沈黎阳 徐国柱 刘丽京 俞立英 陈清棠 郝中顺 王杰军 曹斌融 朱天岳 |
| 作者单位： | 1. 北京大学中国药物依赖性研究所,北京,100083 2. 复旦大学华山医院,上海,200040 3. 北京大学第一医院,北京,100034 4. 第二军医大学长征医院,上海,200003 5. 复旦大学妇产医院,上海,200011 |
| 摘 要： | 目的 :观察复方磷酸可待因片的临床镇痛效果和不良反应。方法 :采用多中心随机双盲对照试验和开放试验设计。以氨酚待因为对照药 ,设单次给药、3d给药、1周给药组 ;分别用于治疗牙痛、痛经、神经性头痛、癌痛和骨科慢性疼痛。镇痛效果评定指标为疼痛强度差、总疼痛强度差、疼痛缓解率、有效率。结果 :复方磷酸可待因片与氨酚待因片的效果基本一致 ,其不良反应较低 ,主要为胃不适、头晕和嗜睡等。结论 :复方磷酸可待因片是安全有效的镇痛药 |
| 关 键 词： | 复方磷酸可待因 氨酚待因 镇痛药 临床试验 |
| 修稿时间： | 2002-07-17 |
CLINICAL EVALUATION OF ANALGESIC EFFECT OF COMPOUND CODEINE PHOSPHATE TABLETS |
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| SHEN Liyang ,XU Guozhu ,LIU Lijing ,YU Liying ,CHEN Qingtang ,HAO Zhongshun ,WANG Jiejun ,CAO Binrong ,ZHU Tianyue. CLINICAL EVALUATION OF ANALGESIC EFFECT OF COMPOUND CODEINE PHOSPHATE TABLETS[J]. Chinese Journal of Drug Dependence, 2003, 12(1): 34-39 | |
| Authors: | SHEN Liyang XU Guozhu LIU Lijing YU Liying CHEN Qingtang HAO Zhongshun WANG Jiejun CAO Binrong ZHU Tianyue |
| Affiliation: | SHEN Liyang 1,XU Guozhu 1,LIU Lijing 1,YU Liying 2,CHEN Qingtang 3,HAO Zhongshun 2,WANG Jiejun 4,CAO Binrong 5,ZHU Tianyue 3 1 |
| Abstract: | Objective : To evaluate the analgesic effect and safety of compound codeine phosphate tablets. Methods : A multicenter, randomized, double blind, parallel group controlled study was performed in 70 patients with dental pain and 60 patients with headache . Paracetamol codeine tablets were used as positive control . An open study was performed in 30 patients with chronic cancer pain,20 patients with chronic non-cancer pain and 20 patients with menorrhalgia . Results : Compound codeine phosphate tablets were effective in the control of moderate pain. There was no significant difference between compound codeine phosphate tablets and paracetamol codeine tablets . The adverse reaction of compound codeine phosphate tablets and paracetamol codeine tablets showed similar profile . They were stomach upset, dizziness and drowsiness. Conclusion : Compound codeine phosphate tablet is an effective and safe analgesic for moderate pain. |
| Keywords: | compound codeine phosphate tablets paracetamol codeine tablets analgesics clinical trial |
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