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| A STUDY OF MULTI-GENE EXPRESSION IN THE HIGHLY METASTASIZING HUMAN OVARIAN CANCER CELL LINE HO-8910PM AND ITS MOTHER CELL LINE HO-8910 | |
| 引用本文： | 倪型灏,许沈华,吴雄伟,张谷,钱丽娟,高永良. A STUDY OF MULTI-GENE EXPRESSION IN THE HIGHLY METASTASIZING HUMAN OVARIAN CANCER CELL LINE HO-8910PM AND ITS MOTHER CELL LINE HO-8910[J]. 中国癌症研究, 1998, 10(3): 174-177. DOI: 10.1007/BF02948355 |
| 作者姓名： | 倪型灏 许沈华 吴雄伟 张谷 钱丽娟 高永良 |
| 作者单位： | Ni Xinghao 1 Xu Shenhua 1 Wu Xiongwei 2 Zhang Gu 1 Qian Lijuan 1 Gao Yongliang 1 1Zhejiang Cancer Hospital，Hangzhou 310022; 2Yiwu People's Hospital，Yiwu |
| 摘 要： | Ｒｅｓｅａｒｃｈｅｓｏｆｔｕｍｏｒｍｏｌｅｃｕｌａｒｂｉｏｌｏｇｙｉｎｒｅｃｅｎｔｙｅａｒｓｈａｖｅｐｒｏｖｅｄｔｈａｔｐｒｏｔｏｏｎｃｏｇｅｎｅａｎｄｔｕｍｏｒｓｕｐｒｅｓｏｒｇｅｎｅｐｌａｙｖｅｒｙｉｍｐｏｒｔａｎｔｒｏｌｅｉｎｔｈｅｐｒｏｃｅ... |
A study of multi-gene expression in the highly metastasizing human ovarian cancer cell line HO-8910PM and its mother cell line HO-8910 |
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| Xinghao Ni,Shenhua Xu,Xiongwei Wu,Gu Zhang,Lijuan Qian,Yongliang Gao. A study of multi-gene expression in the highly metastasizing human ovarian cancer cell line HO-8910PM and its mother cell line HO-8910[J]. Chinese Journal of Cancer Research, 1998, 10(3): 174-177. DOI: 10.1007/BF02948355 | |
| Authors: | Xinghao Ni Shenhua Xu Xiongwei Wu Gu Zhang Lijuan Qian Yongliang Gao |
| Affiliation: | (1) Zhejiang Cancer Hospital, 310022 Hangzhou;(2) Yiwu People’s Hospital, Yiwu |
| Abstract: | Objective: To investigate multi-gene expression in the highly metastasizing human ovarian cancer cell line HO-8910PM and its mother cell line HO-8910. Method: The expression of 9 kinds of gene products in HO-8910PM and its mother cell line HO-8910 was detected by S-P immunohistochemical method. Result: Eight kinds oncogene products showed various degrees of positive expression in both HO-8910PM and HO-8910 cell lines except gene bax. The expression of P53, Cyclin D1, CD44 v6 and EGFR in HO-8910PM was stronger than that in HO-8910. However, the expression of P16, nm23 in HO-8910PM was weaker than that in HO-8910. There was no significant difference on the expression of C-erbB-2 andbcl-2 between the two cell lines. Conclusion: Stronger invasive and metastatic patential is found in HO-8910PM than that in HO-8910. Carcinogenesis is a result of multi-oncogene and multiple step process cooperation. This work was supported by grants from the Zhejiang Natural Science Foundation (No. 396410). |
| Keywords: | Ovarian cancer Oncogene Tumor suppresser gene Immunohistochemistry. |
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