动脉粥样硬化的预防和药物治疗进展

近年来大量的研究提示心血管疾病风险因素在全球范围内呈现暴发状态。一级预防是最好的方法 ,可降低心血管疾病的风险。动脉粥样硬化是心血管疾病的病理基础,动脉粥样硬化开始于幼儿期,相关数据证明,积极治疗应始于早期并持续多年。指南推荐在医生处方指导下使用他汀类药物用于一级预防。他汀类药物是不可替代的、有临床依据的稳定斑块降低心血管危险的主要＂武器＂。近年来随着临床与基础研究的不断深入,如磷脂酶A抑制剂等新的药物被不断发现、研究,同时,烟酸这样的老药,随着新模式的出现和不同角度研究的聚焦,也会受到新的关注。

Progress of prevention and drug therapy in atherosclerosis

A recent outbreak in the amount of cardiovascular risk has swept across the globe. Primary prevention is the preferred method to lower cardiovascular risk. Pathological and epidemiological data confirm that atherosclerosis begins in early childhood, and advances seamlessly and inexorably throughout life. When indicated, aggressive treat-ment should begin at the earliest indication, and be continued for many years. Using statins for primary prevention is recommended by guidelines, is prevalent, but remains under prescribed. Statin drugs are unrivaled, evidence-based,major weapons to lower cardiovascular risk. In recent years, with the deepening of clinical and basic research, such as new drugs PLA2 inhibitors have been discovered, research, while older drugs like niacin, with the focus on the emer-gence of new patterns and different angles of the study, also receive new attention.