Spontaneous abortion following mid-trimester amniocentesis. Clinical significance of placental perforation and blood-stained amniotic fluid |
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| Authors: | B KAPPEL J NIELSEN K BROGAARD HANSEN M MIKKELSEN AA J THERKELSEN |
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| Institution: | The Cytogenetic Laboratory, Århus Psychiatric Hospital, DK-8240 Risskov, Denmark;Department of Obstetrics and Gynaecology, Århus Kommunehospital, DK-8000 Århus, Denmark;The Chromosome Laboratory, J. F. Kennedy Institute, DK-2600 Glostrup, Denmark;Institute of Human Genetics, University of Århus, DK-8000 Århus, Denmark |
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| Abstract: | Summary. The clinical significance of placental perforation and bloodstained amniotic fluid was studied in a group of 7238 Danish women undergoing mid-trimester amniocentesis for prenatal diagnosis under ultrasound guidance. The risk of spontaneous abortion was significantly increased both in pregnancies where the placenta was perforated and in those with blood-stained amniotic fluid. The risk estimate nearly doubled after placental perforation and more than doubled with a bloody tap. It is concluded that for women at relatively low risk of a fetal genetic abnormality, the indication of the amniocentesis should be reconsidered if a placental perforation is unavoidable. |
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