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Population Pharmacokinetics of Temozolomide in Cancer Patients
Authors:Jen  J. Frank  Cutler   David L.  Pai  Sudhakar M.  Batra  Vijay K.  Affrime  Melton B.  Zambas  Demetris N.  Heft  Samuel  Hajian  Gerald
Affiliation:(1) Department of Statistics, Schering-Plough Research Institute, Kenilworth, New Jersey, 07033;(2) Department of Statistics, 2015 Galloping Hill Road, K-15-2-2125, Kenilworth, NJ, 07033;(3) Department of Clinical Pharmacology, Schering-Plough Research Institute, Kenilworth, New Jersey, 07033;(4) Department of Drug Metabolism and Pharmacokinetics, Schering-Plough Research Institute, Kenilworth, New Jersey, 07033
Abstract:
Keywords:temozolomide  cancer  population pharmacokinetics  nonlinear mixed-effects models  pharmacokinetics-toxicity relationship
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