Pattern of cerebral hypoperfusion according to the clinical staging in dementia with Lewy bodies |
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| Authors: | Kyung Won Park Yun Jeong Hong Jong Hwan Park Hyuntae Park Sang Myung Cheon Jae Woo Kim |
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| Affiliation: | 1. Department of Neurology, Cognitive Disorders and Dementia Center, College of Medicine, Dong-A University, Busan, Korea;2. Institute of Convergence Bio-Health, Dong-A University, Busan, Korea;3. Biomedical Research Institute, Pusan National University Hospital, Busan, Korea;4. Institute of Convergence Bio-Health, Dong-A University, Busan, Korea;5. Department of Health Care Science, Dong-A University, Busan, Korea |
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| Abstract: | This study aimed to detect different patterns of cerebral hypoperfusion in DLB according to clinical staging. Thirty-three patients with DLB were recruited by clinical dementia rating (CDR) stage. Compared with control, cerebral hypoperfusion was mainly observed in the lingual gyrus, the cuneus, the occipital gyrus in CDR 0.5 group; the fusiform gyrus, the middle temporal gyrus, and the posterior cingulate in CDR 1; and the lingual gyrus, the cuneus, the hippocampus, the fusiform gyrus, and the inferior frontal gyrus in CDR 2. Our findings suggest that cerebral hypoperfusion spreads to the frontal cortex and temporal lobes as disease progresses. |
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| Keywords: | Dementia with Lewy bodies SPECT regional cerebral blood flow progression clinical dementia rating |
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