| 肝素早期抗凝对内毒素致急性肺损伤大鼠凝血功能的影响 |
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| 引用本文： | 王涛,刘红,马京,任雪燕.肝素早期抗凝对内毒素致急性肺损伤大鼠凝血功能的影响[J].宁夏医学杂志,2009,31(4):307-308. |
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| 作者姓名： | 王涛 刘红 马京 任雪燕 |
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| 作者单位： | 宁夏医科大学附属医院,宁夏,银川,750004 |
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| 摘 要： | 目的观察内毒素致急性肺损伤大鼠的凝血功能变化及肝素早期抗凝治疗的效果。方法健康雄性SD清洁级大鼠50只,随机分为5组。A1-A3及B组均尾静脉注射大肠杆菌脂多糖（LPS）5mg/kg,A1-A3组分别在给予LPS后1min静注肝素100U/100g、50U/100g、25U/100g,C组给予等容量的生理盐水。B组在LPS注射前和注射后1min、4h,A1-A3组和C组4h经右股静脉取静脉血检测血浆凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、凝血酶时间（TT）、血浆纤维蛋白原水平（FIB）。结果LPS注射1min后B组PT、TT缩短,FIB减少。LPS注射4h后,与C组比较,B组PT、APTT延长,FIB减少（P〈0.05）;与B组比较,A1-A3组FIB显著增加（P〈0.01）;A1组和A2组TT显著延长（P〈0.01）;A1组APTT显著延长（P〈0.01）。结论肝素早期抗凝治疗对内毒素性急性肺损伤大鼠凝血紊乱有改善作用,小剂量治疗较适宜。
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| 关 键 词： | 急性肺损伤 内毒素 肝素 凝血 |
The effects of prophylactic heparin on acute lung injury coagulopathy in endotoxemic rats |
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| WANG Tao,LIU Hong,MA Jing,et al..The effects of prophylactic heparin on acute lung injury coagulopathy in endotoxemic rats[J].Ningxia Medical Journal,2009,31(4):307-308. |
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| Authors: | WANG Tao LIU Hong MA Jing |
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| Institution: | The Affiliated Hospital of Ningxia Medical University;Yinchuan 750004;China |
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| Abstract: | Objective To investigate the effects of prophylactic hparin on acute lung injury (ALI) coagulopathy in endotoxemic rats.Methods Fifty male SD rats weighing 250-300g were randomly divided into 5 groups with 10 animals in each group: in group A1-A3 1min after lipopolysaccharide (LPS 5mg/kg) heparin 100u /100g, 50u/100g, 25u /100g were infused by vena caudalis; group B received LPS 5 mg/kg; group C served as control one by giving the same volume of saline. The animals were anesthetized with 3% pentobarbital 40... |
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| Keywords: | Acute lung injury Heparin Endotoxin Coagulopathy |
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