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| mTOR和4EBPS在乳腺浸润性导管癌中的表达及意义 | |
| 引用本文： | 胡爱侠,张云汉. mTOR和4EBPS在乳腺浸润性导管癌中的表达及意义[J]. 肿瘤学杂志, 2011, 17(3): 180-183 |
| 作者姓名： | 胡爱侠 张云汉 |
| 作者单位： | 1. 商丘市中心医院,河南,商丘,476000;郑州大学基础医学院,河南省肿瘤病理重点实验室,河南,郑州,450005 2. 商丘市中心医院,河南,商丘,476000 |
| 摘 要： | [目的]探讨mTOR和4EBPS在乳腺浸润性导管癌中的表达及意义。[方法]采用免疫组化SP法检测45例乳腺癌及癌旁正常组织中mTOR和4EBPS的表达。[结果]mTOR在乳腺癌中的阳性率为75.56%（34/45）,在正常乳腺组织中的阳性率为20.00%（9/45）,差异有显著性（P〈0.05）。mTOR表达与乳腺癌淋巴结转移明显相关（P〈0.05）。4EBPS在乳腺癌中的阳性率为31.11%（14/45）,在正常乳腺组织中的阳性率为95.56%（43/45）,差异有显著性（P〈0.05）。4EBPS表达与乳腺癌淋巴结转移无关（P〉0.05）。mTOR与4EBPS表达呈负相关（r=-0.614,P〈0.05）。[结论]mTOR和4EBPS在乳腺癌组织中的异常表达可能与乳腺癌的发生有关,且mTOR的异常表达可能与乳腺癌的转移有关。 |
| 关 键 词： | mTOR 4EBPS 乳腺肿瘤 浸润性导管癌 免疫组化 |
Expression of mTOR and 4EBPS in Invasive Ductal Carcinoma of the Breast and its Significance |
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| HU Ai-xia,ZHANG Yun-han. Expression of mTOR and 4EBPS in Invasive Ductal Carcinoma of the Breast and its Significance[J]. Journal of Chinese Oncology, 2011, 17(3): 180-183 | |
| Authors: | HU Ai-xia ZHANG Yun-han |
| Affiliation: | HU Ai-xia1,2,ZHANG Yun-han1(1.Shangqiu Municipal Central Hospital,Shangqiu 476000,China,2.Basic Medical College of Zhengzhou University,Henan Key Laboratory for Tumor Pathology,Zhengzhou 450005,China) |
| Abstract: | [Purpose] To investigate the expression of mTOR and 4EBPS in invasive ductal carcinoma of the breast and its significance.[Method] The expression of mTOR and 4EBPS in 45 cases with breast cancer tissue and 45 cases with cancer adjacent tissue was detected by immunohistochemistry(SP method).[Results] The positive rate of mTOR in breast cancer tissue and cancer adjacent tissue was 75.56%(34/45) and 20.00%(9/45),respectively,with significant difference(P<0.05).And the expres-sion of mTOR was related to lymph n... |
| Keywords: | mTOR 4EBPS breast neoplasms invasive ductal carcinoma immunohistochemistry |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |