尿NAG、mALB、β_2-MG、α_1-MG检测对早期肾损害的诊断价值

目的探讨尿N-乙酰-β-D-氨基葡萄糖苷酶（NAG）、微量白蛋白（mALB）、β2-微球蛋白（β2-MG）、α1-微量球蛋白（α1-MG）检测对早期肾损害的诊断价值及临床意义。方法将150例受试者分为健康对照组（为门诊健康体检人群）和病例组（均为我科门诊和住院患者）。分别检测两组尿NAG、mALB、β2-MG、α1-MG的含量,并对检测结果进行比较及统计学分析。结果病例组检测的阳性率及4项检测指标结果均显著高于健康对照组,病例组4项检测指标尿NAG、β2-MG、mALB、α1-MG的阳性率分别为82.1%、70.5%、64.2%和41.0%,尿NAG的敏感性高于尿mALB、β2-MG、α1-MG,差异有统计学意义（P〈0.001）。尿β2-MG的敏感性高于尿mALB、α1-MG,差异有统计学意义（P〈0.05）。结论尿NAG、β2-MG检测对早期肾损害更具有敏感性,可作为肾损害性疾病的早期诊断、疗效观察的有效指标。

Diagnostic value of urinary NG, mALB, β2-MG and α1-MG in early renal injury

Objective To investigate the diagnostic value and clinical significance of urinary NAG,mALB,β2-MG and α1-MG in early renal injury.Methods 150 subjects were divided into control group（healthy people for the outpatient） and case group（all my outpatients and inpatients）.The urinary NAG,mALB,β2-MG and α1-MG were measured.Results The positive rate and NAG,mALB,β2-MG and α1-MG were significantly higher than that of the control group.The positive rates of urinary NAG,MALB,β2-MG and α1-MG were 82.1%,70.5%,64.2% and 41.0%,respectively.The sensitivity of urinary NAG was higher than that of the other three group（P0.001）.The urinary β2-MG was more sensitive than urinary mALB and α1-MG（P0.05）.Conclusions Urinary NAG and β2-MG can be used as the sensitive indicates of the diagnosis and therapeutic effective in early renal injury.