阻塞性睡眠呼吸暂停低通气综合征患者睡眠结构研究

目的研究阻塞性睡眠呼吸暂停低通气综合征（Obstructive Sleep Apnea-Hypopnea Syndrome,OSAHS）患者的睡眠结构改变并探讨其临床意义。方法在纳入研究的108例患者中，经多导睡眠图（PSG）检查确诊OSAHS患者81例，其中轻度、中度以及重度组分别27例，对照组（单纯鼾症组）27例，比较各组觉醒时间、非快速眼动（NREM）、快速眼动（REM）睡眠各期所占比例计算其百分比；比较各组呼吸暂停低通气指数（apnea—hypopnea index，AHI）、体质指数（BMI）、微觉醒指数（MI，次／h）的差别；对各组AHI与S3＋S4期睡眠百分比、MI的相关性进行分析。结果各OSAHS组觉醒时间、S2、S3＋S4期睡眠、REM期睡眠均显著高于单纯鼾症对照组（P〈0.05）；S1期睡眠重度OSAHS组显著高于对照组（P〈0．05），轻、中度0sAHs组和对照组差异不具有显著性（P〉0．05）；MI中、重度OSAHS组显著高于对照组（P〈0．05），轻度OSAHS组和对照组差异不具有显著性（P〉0．05）；各组的AHI与S3＋S4期睡眠百分比、MI的Pearson相关系数分别为-0．478和0．785，具有良好的相关性。结论0SAHS患者觉醒时间增加、深睡眠减少、微觉醒增加，睡眠结构严重紊乱，从而产生白天嗜睡、记忆力下降、智力障碍以及个性改变等一系列脑功能障碍的临床症状。

Sleeping structure in patients with obstructive sleep apnea-hypopnea syndrome

Objective To investigate the sleep structure in patients with obstructive sleep apnea-hypopnea syndrome(OSAHS).Methods 108 patients with snoring during night were diagnosed by polysomnography(PSG) and divided into 4 groups by apnea-hypopnea index(AHI),including snorer,mild,middle and sever group.There were 27 cases for each group.The percentage of sleep stages of non-rapid eye movement(NREM) and rapid eye movement(REM),body mass index(BMI) and microarousal index(MI) were analyzed.Results The awaking time wa...