糖尿病家族史、饮食及肥胖与糖尿病交互作用

目的 探讨糖尿病家族史、饮食及肥胖与糖尿病的交互作用。方法选取对湖南省长沙市望城县3个村所有≥15岁常住居民1 602人,调查社会人口资料、糖尿病家族史、饮食习惯及身高、体重、腰臀比、血糖值以及体育锻炼等情况,并对因素间的交互作用进行分析。结果 望城县农村居民糖尿病年龄标化患病率为5.35%,糖尿病家族史与向心性肥胖、年龄≥45岁、文化程度低及高脂饮食间均存在相加交互作用,其交互作用超额相对危险度(RERI)分别为6.2997、7.1803、3.500、3.020,向心性肥胖与高脂饮食间存在相加交互作用,RERI为6.642。结论 糖尿病家族史、饮食及肥胖间存在相加交互作用。

Interactive effcets of family history of diabetes,diet and obesity on type 2 diabetes mellitus

Objective To explore the interactive effcts of family history of diabetes,diet and obesity on type 2 diabetes mellitus.Methods Totally 1 602 rural residents in Wangcheng county were investigated to collect information on their socio-demographics,family history of diabetes,diet structure,height,weight,waist-to-hip ratio,blood glucose,and other risk factors of diabetes.All significant risk factors in single-factor analysis were analyzed to find out additive interaction.Results The age-standardized morbidity of type 2 diabetes in the residents was 5.35%.Additive interactions were detected between family history and age ≥45 years with a relative excess risk of interaction(RERI) of 6.299,between family history and central obesity(RERI=7.180),between family history and low education level(RERI=3.500),between family history and fatty diet(RERI=3.020),and between central obesity and fatty diet(RERI=6.642).Conclusion There are aditive interactions between family history of diabetes,diet and obesity as the risk factors for type 2 diabetes millitus.