Effects of a Multicomponent Frailty Prevention Program in Prefrail Community-Dwelling Older Persons: A Randomized Controlled Trial |
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| Affiliation: | 1. Jockey Club Institute of Ageing, Chinese University of Hong Kong, Hong Kong SAR, China;2. Department of Medicine and Therapeutics, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong SAR, China;3. Jockey Club Cadenza Hub, Hong Kong SAR, China;1. Geriatric Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy;2. Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy;3. The Cecil G. Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, Chapel Hill, NC;4. School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC;5. Schools of Social Work and Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC;1. Rehabilitation, South Karelia Social and Health Care District, Lappeenranta, Finland;2. Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland;3. Unit of Primary Health Care, University of Helsinki, Department of General Practice, and Helsinki University Hospital, Helsinki, Finland;4. Raatimiehet Oy, Lappeenranta, Finland;5. Faculty of Sport and Health Sciences, Gerontology Research Center, University of Jyväskylä, Jyväskylä, Finland;1. Clalit Health Services (CHS), Northern District, Israel;2. The Azrieli Faculty of Medicine in Galilee, Bar-Ilan University, Safed, Israel;3. International Group for Reducing Inappropriate Medication Use & Polypharmacy (IGRIMUP), Bat Yam, Israel;4. Department of Family Medicine, Sial Research Center for Family Medicine and Primary Care, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel;5. Unit for Community Geriatrics, Division of Health in the Community, Ben-Gurion University of the Negev, Beer-Sheva, Israel;6. Department of Geriatrics, Soroka Medical Center, Beer-Sheva, Israel;1. Human Performance and Sports Science Laboratory, University of Murcia, Murcia, Spain;2. Navarrabiomed, Complejo Hospitalario de Navarra (CHN), Universidad Pública de Navarra (UPNA), IdiSNA, Pamplona, Spain;3. CIBER of Frailty and Healthy Aging (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain;1. Division of Geriatric Medicine, Department of Medicine, National University Hospital, National University Health System, Singapore, Singapore;2. Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore;3. Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore;4. Regional Health Services Planning Office, National University Health System, Singapore, Singapore |
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| Abstract: | ![]()
ObjectiveTo examine the effects of a multicomponent frailty prevention program in community-dwelling older persons with prefrailty.DesignA randomized controlled trial.SettingA community elderly center in Hong Kong.ParticipantsPersons aged ≥50 years who scored 1-2 on a simple frailty questionnaire (FRAIL)MethodsParticipants (n = 127) were randomly assigned to a 12-week multicomponent frailty prevention program (exercise, cognitive training, board game activities) or to a wait-list control group. The primary outcomes were FRAIL scores, frailty status, and a combined frailty measure including subjective (FRAIL total score) and objective (grip strength, muscle endurance, balance, gait speed) measures. The secondary outcomes were verbal fluency assessed by dual-task gait speed, attention and memory assessed by digit span task, executive function assessed by the Frontal Assessment Battery, self-rated health, and life satisfaction. Assessments were conducted at baseline and at week 12.ResultsThe mean age of the participants was 62.2 years, and 88.2% were women. At week 12, the FRAIL score had decreased in the intervention group (−1.3, P < .001) but had increased in the control group (0.3, P < .01) (between-group differences P < .001). In addition, 83.3% and 1.6% of the intervention and control groups, respectively, had reversed from prefrailty to robust phenotype (between-group differences P < .001). Participants in the intervention group also had a greater reduction in the combined frailty score and greater improvements in muscle endurance, balance, verbal fluency, attention and memory, executive function, and self-rated health than those in the control group (all P < .05). There were no significant differences between the groups with respect to grip strength, gait speed, and life satisfaction.Conclusions and implicationsThe multicomponent frailty prevention program reduced frailty and improved physical and cognitive functions, and self-rated health in community-dwelling older persons with prefrailty. Findings can provide insights into the consideration of incorporating frailty prevention programs into the routine practice of community elderly services. |
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| Keywords: | Frailty multicomponent randomized controlled trial |
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