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Vitamin B6 Addiction in Acute Myeloid Leukemia |
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| Affiliation: | 1. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA;2. Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;3. Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY 10065, USA;4. Donald B. and Catherine C. Marron Cancer Metabolism Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;5. Howard Hughes Medical Institute, New York, NY 10065, USA |
| Abstract: |  |
| Keywords: | acute myeloid leukemia selective metabolic dependency pyridoxal kinase vitamin B6 pyridoxal phosphate PLP-dependent enzyme CRISPR/Cas9 functional genomics therapeutic target B cell lymphoma-2 ABT-199/venetoclax |
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