乳腺病中血清层粘连蛋白含量的变化

利用ＥＬＩＳＡ法检测了乳腺小叶增生、良性纤维瘤和恶性浸润性导管癌患者血清层粘连蛋白的含量，比较了乳腺良恶性病患者及正常人之间ＬＮ的差异。结果表明，恶性肿瘤病人ＬＮ值之间有显著差异（Ｐ〈０．０１），良性病人与正常人之间无显著差异，（Ｐ〉０．０５），本文还发现纤维瘤与正常人之间ＬＮ有显著差异（Ｐ≤０．０５），但小叶增生与正常人，纤维瘤之间ＬＮ无显著差异（Ｐ〉０．０５），由于乳腺病从良性转变为恶性，患者

The variation of serum laminin level in breast diseases

Serum laminin (sLN) levels in patients of breast tissue proliferation disease, benign fibroma and malignant invasive ductal carcinoma were mpasured by ELISA, in comparison with normal control subjects. The results showed that sLN level in malignant tumors was significantly higher than in normal controls and benign tumors (P< 0.01), but the difference between benign tumors and controls was not significant (P>0. 05). Meanwhile, sLN level of benign fibroma was significantly higher than that of normal control (P< 0.05) , but there was no significant difference between benign proliferation and normal control (P>0.05). We can conclude that sLN level increases during the development of breast disease from benign to malignant, and the determination of sLN may be a useful test in breast tumor.