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| Effects of Acute Mechanical Stretch on the Expression of Mechanosensitive Potassium Channel TREK-1 in Rat Left Ventricle | |
| 引用本文： | 赵芳,董黎娟,程龙献,曾秋棠,苏方成. Effects of Acute Mechanical Stretch on the Expression of Mechanosensitive Potassium Channel TREK-1 in Rat Left Ventricle[J]. 华中科技大学学报(医学英德文版), 2007, 27(4): 385-387. DOI: 10.1007/s11596-007-0409-2 |
| 作者姓名： | 赵芳 董黎娟 程龙献 曾秋棠 苏方成 |
| 作者单位： | Department of Cardiology Union Hospital，Tongji Medical College，Huazhong University of Science and Technology，Department of Internal Medicine，Wujiashan Hospital of Hongxihu District，Department of Cardiology，Union Hospital，Tongji Medical College，Huazhong University of Science and Technology，Department of Cardiology，Union Hospital，Tongji Medical College，Huazhong University of Science and Technology，Department of Cardiology，Union Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430022，China，Wuhan 430040，China，Wuhan 430022，China，Wuhan 430022，China，Wuhan 430022，China |
| 摘 要： | To explore the role of mechanosensitive potassium channel TREK-1, Western blot analysis was used to investigate the expression changes of TREK-1 in left ventricle in acute mechanically stretched heart. Forty Wistar rats were randomly divided into 8 groups （n=5 in each group）, subject to single Langendorff perfusion for 0, 30, 60, 120 min and acute mechanical stretch for 0, 30, 60, 120 min respectively. With Langendorff apparatus, an acute mechanically stretched heart model was established. There was no significant difference in the expression of TREK-1 among single Langendorff perfusion groups （P〉0.05）. As compared to non-stretched Langendorff-perfused heart, only the expression of TREK-1 in acute mechanically stretched heart （120 min） was greatly increased （P〈0.05）. This result suggested that some course of mechanical stretch could up-regulate the expression of TREK-1 in left ventricle. TREK-1 might play an important role in mechanoelectric feedback, so it could reduce the occurrence of arrhythmia that was induced by extra mechanical stretch. |
| 关 键 词： | 钾离子通道 基因表达 机械延伸 病理 |
| 收稿时间： | 2006-12-29 |
| 修稿时间： | 2006-12-29 |
Effects of acute mechanical stretch on the expression of mechanosensitive potassium channel TREK-1 in rat left ventricle |
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| Zhao Fang,Dong Lijuan,Cheng Longxian,Zeng Qiutang,Su Fangcheng. Effects of acute mechanical stretch on the expression of mechanosensitive potassium channel TREK-1 in rat left ventricle[J]. Journal of Huazhong University of Science and Technology. Medical sciences, 2007, 27(4): 385-387. DOI: 10.1007/s11596-007-0409-2 | |
| Authors: | Zhao Fang Dong Lijuan Cheng Longxian Zeng Qiutang Su Fangcheng |
| Affiliation: | 1. Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022,China 2. Department of Internal Medicine, Wujiashan Hospital of Hongxihu District, Wuhan 430040, China |
| Abstract: | To explore the role of mechanosensitive potassium channel TREK-1,Western blot analysis was used to investigate the expression changes of TREK-1 in left ventricle in acute me-chanically stretched heart.Forty Wistar rats were randomly divided into 8 groups(n=5 in each group),subject to single Langendorff perfusion for 0,30,60,120 min and acute mechanical stretch for 0,30,60,120 min respectively.With Langendorff apparatus,an acute mechanically stretched heart model was established.There was no significant difference in the expression of TREK-1 among single Lan-gendorff perfusion groups(P>0.05).As compared to non-stretched Langendorff-perfused heart,only the expression of TREK-1 in acute mechanically stretched heart(120 min) was greatly increased(P<0.05).This result suggested that some course of mechanical stretch could up-regulate the expres-sion of TREK-1 in left ventricle.TREK-1 might play an important role in mechanoelectric feedback,so it could reduce the occurrence of arrhythmia that was induced by extra mechanical stretch. |
| Keywords: | mechanoelectric feedback mechanosensitive potassium channel mechanical stretch |
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