| 异基因骨髓移植治疗Bruton病 |
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| 引用本文： | 黄晓军,石红霞,郭乃榄,陆道培. 异基因骨髓移植治疗Bruton病[J]. 中华血液学杂志, 2002, 23(10): 528-530 |
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| 作者姓名： | 黄晓军 石红霞 郭乃榄 陆道培 |
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| 作者单位： | 100044,北京大学人民医院血液病研究所 |
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| 摘 要： | 目的 探讨异基因骨髓移植（allo-BMT)治疗X连锁无丙种球蛋白血症（Bruton病）的疗效。方法 采用HLA配型相合的同胞allo-BMT治疗Bruton病2例。其中例1进行了2次ABO血型相合，HLA相合的allo-BMT。结果 2例患者分别于allo-BMT后第20天和第13天骨髓恢复造血，免疫球蛋白在3个月内逐渐恢复正常；患者的体液免疫重建。生活质量得到明显提高，2例现在仍无病存活13年和2年。2例患者均未出现严重的移植物抗宿主病。结论 造血干细胞移植可用于Bruton病的治疗。
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| 关 键 词： | 骨髓移植 X连锁无丙种球蛋白血症 移植物抗宿主病 治疗 Bruton病 |
| 修稿时间： | 2001-11-21 |
Allogeneic bone marrow transplantation for the treatment of Bruton disease |
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| HUANG Xiaojun,SHI Hongxia,GUO Nailan,LU Daopei. Allogeneic bone marrow transplantation for the treatment of Bruton disease[J]. Chinese Journal of Hematology, 2002, 23(10): 528-530 |
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| Authors: | HUANG Xiaojun SHI Hongxia GUO Nailan LU Daopei |
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| Affiliation: | Institute of Hematology, People's Hospital, Peking University, Beijing 100044, China. |
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| Abstract: | Objective To explore the efficacy of allogeneic bone marrow transplantation(allo-BMT) for the treatment of Bruton disease.Methods HLA-matched sibling bone marrow transplantation was performed for the treatment of 2 cases of X-linked agammaglobulinemia. One of them received allo-BMT twice.Results Recovery of hematopoiesis was gained at day 20 and day 13 after allo-BMT in the two cases respectively.Serum immunoglobin rose gradually to normal level in three months.Their humoral immuno-system was reconstituted and life quality improved. These two patients are still in disease-free survival for 13 and 2 years respectively.There was no serious graft-versus-host-disease. Conclusion Stem cell transplantation is a choice for the treatment of Bruton disease. |
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| Keywords: | Bone marrow transplantation X-linked agammaglobulinemia Graft versus host disease |
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