非甾体抗炎药相关性上消化道出血的临床分析

目的 探讨非甾体抗炎药(NSAIDs)相关性上消化道出血的临床及内镜特点.方法 对177例上消化道出血病人的临床资料进行回顾性分析,根据出血前1周内是否服用NSAIDs分为NSAIDs组(36例)和非NSAIDs组(141例).对比分析两组患者的临床资料.结果 177例上消化道出血患者中有36例(20.34%)服用过NSAIDs.两组比较,NSAIDs组在年龄、溃疡类型、临床症状等方面均有显著差异,但在性别、Hp阳性率、既往溃疡病史上无显著性差异.结论 加强对非甾体抗炎药相关性上消化道出血的认识,合理用药,并采取相应措施,以降低使用NSAIDs引起上消化道出血的风险.

Clinical analysis of non-steroidal anti-nflammatory drugs associated upper gastrointestinal bleeding

Objective To evaluate the clinical characteristics of non-steroidal anti-inflammatory drugs (NSAIDs) associated upper gastrointestinal bleeding. Methods Clinical datas of 177 patients with upper gastrointestinal bleeding were analysed retroversionally. Patients were divided into two groups based on whether consumed NSAIDs within 7 days previous to the onset of bleeding. Results 36(20.34%) of 177 patients with upper gastrointestinal bleeding consumed NSAIDs. There was significantly difference between NSAIDs group and no NSAIDs group in age of patients,types of ulcer,clinical symptom. But there was no significant difference in sex and Helicobacter pylori(HP) infection. Conclusions The clinical characteristics of NSAIDs associated upper gastrointestinal bleeding. should be better understood so as to decrease the occurrence of NSAIDs ulcer and its complication.