Preoperative Localization of Parathyroid Adenomas Using 99mTc-MIBI Scintigraphy in Patients with Hyperparathyroidism |
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| Authors: | Shoichi Ebisuno Takeshi Inagaki Toshihiko Yoshida Motoki Yamamoto Yoji Tabuse Yasuo Kohjimoto Tadashi Ohkawa |
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| Affiliation: | Divisions of Urology, Minami Wakayama National Hospital, Wakayama, Japan;Surgery, Minami Wakayama National Hospital, Wakayama, Japan;Division of Urology, Wakaura Central Hospital, Wakayama, Japan;Department of Urology, Wakayama Medical College, Wakayama, Japan |
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| Abstract: | ![]()
Background Technetium (Tc) 99m methoxyisobutyl isonitrile (99mTc-MIBI) has recently been introduced for parathyroid imaging, as well as for myocardial imaging. We studied the usefulness of 99mTc-MIBI scintigraphy for preoperative localization of abnormal parathyroid glands.
Methods The usefulness of 99mTc-MIBI scintigraphy for detection of hyperfunctional parathyroid lesions was evaluated in 5 patients with primary hyperparathyroidism. The results of localizing the abnormal glands by using 99mTc-MIBI were compared with those obtained by using thallium (Tl) 201-technetium (Tc) 99m (2ulTI-99mTc) subtraction scintigraphy, computed tomography, and ultrasonography.
Results The delayed (2 hours) imaging of 99mTc-MIBI scintigraphy was highly useful for accurate localization of the abnormal parathyroid lesions. The diseased glands were detected in all cases where 99mTc-MIBI scintigraphy was used, and using 99mTc-MIBI scintigraphy provided more information than did computed tomography, ultrasonography, or 201Tl-99mTc subtraction scintigraphy. Conclusion: This method is simple and essential for detecting hyperfunctioning parathyroid glands, especially those with small or ectopic lesions. This technique should be widely applied as a localizing diagnostic method for hyperparathyroidism. |
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| Keywords: | hyperparathyroidism 99mTc-MIBI scintigraphy localization of parathyroid adenoma |
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