甲状腺球蛋白与甲状腺^99mTc04^-显像对甲状腺结节临床诊断的分析

目的：了解甲状腺球蛋白（Thyroglobulin,TG）与甲状腺^99mTc04^-显像对不同甲状腺结节的诊断价值。方法：用化学发光方法检测血清甲状腺球蛋白的含量;采用静脉注射^99mTc04^-185MBq15m in后行甲状腺前位静态显像,采集总计数300K。217例患者按术后病理诊断分为三组：甲状腺癌38例,甲状腺腺瘤33例,结节性甲状腺肿146例。结果：217例甲状腺患者甲状腺球蛋白阳性的有102例,总阳性率占47%,其中甲状腺癌占19.6%（20/102）,甲状腺腺瘤占25.5%（26/102）,结节性甲状腺肿占54.9%（56/102）;217例患者中131例做了甲状腺^99mTc04^-显像,冷结节为83例,其中甲状腺癌占31.3%（26/83）,甲状腺腺瘤占18.1%（15/83）,结节性甲状腺肿占50.6%（42/83）;凉结节为43例,其中甲状腺癌占27.9%（12/43）,甲状腺腺瘤占34.9%（15/43）,结节性甲状腺肿占37.2%（16/43）。结论：TG的阳性不能作为判断甲状腺结节良恶性的金指标,但TG的升高不可忽视,应引起重视;多种性质的甲状腺疾病均可表现为冷结节,其反映了甲状腺局部组织的无功能或功能低下,但不同的疾病其病理基础和改变不同,冷结节的定性诊断和鉴别诊断必须紧密联系病人的病史及血清甲状腺指标等其他相关检查。

Thyroglobulin and Thyroid 99mTc04- imaging for Clinical Diagnosis of Thyroid Nodules

Objective： To know thyroglobulin and thyroid ^99mTc04^- imaging in the diagnosis of thyroid nodules of different value. Method： Chemiluminescent detection of the content of serum thyroglobulin ; intravenous ^99mTc04^- 185 MBq 15 min later static anterior thyroid imaging. 217 cases of pathological diagnosis of patients divided into three groups： 38 cases of thyroid cancer, 33 cases of thyroid adenoma, 146 cases of nodular goiter. Result ： 102 cases in 217 of thyroid patients with positive thyroglobulin, with a total positive rate of 47%, of which 20 cases of thyroid cancer, 26 cases of thyroid adenoma, 56 cases of nodular goiter; 131 cases in 217 cases of patients make a ^99mTc04^- imaging of the thyroid, cold nodule in 83 cases, 26 cases of thyroid cancer, 15 cases of thyroid adenoma, nodular goiter accounted for 42 cases; cool for 43 cases of nodular, which accounted for 12 cases of thyroid cancer, thyroid gland tumors accounted for 15 cases, nodular goiter accounted for 16 cases. Conclusion： TG should pay attention to the rise; a variety of the nature of thyroid disease can be manifested as cold nodules, which reflects the local tissue thyroid function or function - free low, cold nodule diagnosis of the sick must be a history of close contact and serum thyroid - related inspections, and other target.