Yogurt is tolerated by the majority of children with IgE-mediated cow's milk allergy |
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| Institution: | 1. Allergy Unit, Pediatrics Area, Department of Woman and Child Health, Policlinico Gemelli Universitary Foundation IRCCS, Catholic University of Sacre Hearth, Rome, Italy;2. Allergy Unit, Pediatric Clinic, Civil Hospital, Senigallia, Italy;3. Primary Care Pediatrics, ASL Salerno, Italy;1. Immunology Research Center, Iran University of Medical Sciences, Tehran, Iran;2. Department of Immunology, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran;3. Department of Allergy and Clinical Immunology, Iran University of Medical Sciences, Tehran, Iran;4. Persian Gulf Marine Biotechnology Research Center, Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran;5. Clinical Biochemistry Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran;6. Department of Immunology, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran;7. Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran;1. Allergy Unit, Department of Pediatrics, Anna Meyer Children''s University Hospital, Florence, Italy;2. Department of Surgical, Stomatologic and Mother-Child Sciences, Section of Pediatrics, University of Verona, Verona, Italy;3. Department of Pathology and Diagnostics, Section of Immunology, University of Verona, Verona, Italy;4. Department of Clinical and Experimental Medicine, Section of Pediatrics, University of Pisa, Pisa, Italy;1. Service d’Hépatologie, Gastroentérologie et Nutrition pédiatriques, Hôpital Femme-Mère-Enfant, Hospices Civils de Lyon, Bron, France;2. Service d’Anatomopathologie, Groupement hospitalier Est, Hospices Civils de Lyon, Bron, France;3. Université Claude Bernard Lyon 1, Lyon, France;1. Allergy Unit of the 3rd Pediatric Department, Aristotle University of Thessaloniki, Greece;2. Department of Pediatrics, Democritus University of Thrace, Greece;3. Immunology Unit 1st Pediatric Department, Aristotle University of Thessaloniki, Greece;4. Organ Transplantation Unit, Aristotle University of Thessaloniki, Greece;5. 4th Pediatric Department, Aristotle University of Thessaloniki, Greece |
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| Abstract: | BackgroundChildren with IgE-mediated cow's milk allergy (IgE-CMA) with gastrointestinal symptoms tolerate yogurt at 100%. Yogurt tolerance in children with IgE-CMA with urticaria and anaphylaxis was 7%.MethodsWe enrolled children with IgE-CMA with cutaneous, respiratory, gastrointestinal and anaphylactic symptoms. All performed prick by prick (PbP) and oral food challenge (OFC) with yogurt. Some children performed also an OFC with CM mixed with wheat flour and baked, baked liquid CM, parmesan.Results34 children were enrolled, 31/34 (91%) with systemic adverse reaction after ingestion of CM (systemic CMA), 3/34 (9%) with isolated contact urticaria (ICU CMA). PbP with yogurt was negative only in one patient. OFC with yogurt was passed (that is, the OFC was negative) by 20/31 (64%) of the children with systemic CMA. 10/11 (91%) of the patients who failed OFC (that is, the OFC was positive) with yogurt were positive to SPT with casein vs. 8/20 (40%) of the patients who passed it (p = 0.018). None of the 19 children who passed OFC with yogurt failed all OFC with processed CM forms other than yogurt that tested vs. 4/8 among those who failed OFC with yogurt (p = 0.006). The rub test with yogurt was negative in 1/3 (33%) of the patients with ICU CMA.ConclusionsThe results of our study are placed alongside others already present in the literature and concerning other methods of processing CM proteins and help to reduce the dietary restrictions of the majority of children with systemic IgE-CMA. |
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| Keywords: | Cow's milk allergy Yogurt Oral food challenge Tolerance |
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