| 内皮克隆形成细胞的研究进展 |
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| 引用本文： | 吴晓欣,周建大. 内皮克隆形成细胞的研究进展[J]. 中南大学学报(医学版), 2015, 40(5): 564-568 |
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| 作者姓名： | 吴晓欣 周建大 |
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| 作者单位： | 中南大学湘雅三医院烧伤整形外科，长沙 410013 |
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| 基金项目： | 湖南省卫生计生委科研基金，中南大学大学生创新训练计划项目(201410533322).This work was supported by Scientific Research Foundation of the Health and Family Planning Commission of Hunan Province，the Project of Training Programs of Innovation for Undergraduates from Central South University，P.R.China |
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| 摘 要： | 内皮克隆形成细胞(endothelial colony-forming cells，ECFCs)是一种有别于经典内皮祖细胞的具有强大血管新生功能的晚期内皮祖细胞。ECFCs在心、肺、脑的缺血修复中具有强大的血管生成潜能，在缺血肢体及损伤骨组织的修复中能明显诱导血管相关因子的表达并促进血管新生。ECFCs具有强大的肿瘤归巢效应，与肿瘤的发生发展及预后关系密切，可为血管再生研究、肿瘤治疗、组织再生工程等领域提供新的方向。
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| 关 键 词： | 内皮克隆形成细胞 血管再生 损伤修复 肿瘤 组织工程 |
Advance in study on endothelial colony-forming cells |
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| WU Xiaoxin,ZHOU Jianda. Advance in study on endothelial colony-forming cells[J]. Journal of Central South University. Medical sciences, 2015, 40(5): 564-568 |
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| Authors: | WU Xiaoxin ZHOU Jianda |
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| Affiliation: | Department of Burns and Plastic Surgery, ird Xiangya Hospital, Central South University, Changsha, 410013, China |
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| Abstract: | Endothelial colony-forming cells (ECFCs), diff erent from classical endothelial progenitor cells, arelate endothelial progenitor cells with the capability to promote angiogenesis. Recent studies showedthat ECFCs have a huge angiogenesis potential in the restoration of ischemic hearts, lungs or brains.Th ey are also able to induce the expression of vascular related factor to promote angiogenesis inrepair of limb ischemia or bone injury. Furthermore, ECFCs possess a strong homing effect fortumor, which is closely related to tumor occurrence, development and prognosis. Th us, ECFCs area novel direction for vascular regeneration study, and may lead to ground-breaking progresses infi elds of tissue regeneration and tumor. |
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| Keywords: | endothelial colony-forming cells vascularization repair of injury tumor tissue engineering |
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