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| 子宫内膜癌端粒酶活性研究 | |
| 引用本文： | Zhou C,Sun J,Jin S. 子宫内膜癌端粒酶活性研究[J]. 中华肿瘤杂志, 1998, 20(6): 428-430 |
| 作者姓名： | Zhou C Sun J Jin S |
| 作者单位： | 中国医学科学院中国协和医科大学肿瘤医院肿瘤研究妇瘤科 |
| 摘 要： | 目的探索端粒酶活性与子宫内膜癌发生发展的关系。方法采用ＰＣＲ－ＴＲＡＰ方法检测３４例子宫内膜癌和６例正常子宫内膜组织的端粒酶活性。结果在３４例子宫内膜癌中,２８例端粒酶活性阳性;６例正常子宫内膜组织中,有１例端粒酶活性阳性。结论端粒酶激活与子宫内膜癌的发生发展有密切关系,并有可能成为子宫内膜癌的临床肿瘤标记物 |
| 关 键 词： | 子宫内膜肿瘤 端粒酶 聚合酶链反应 |
Telomerase activity in human primary endometrial carcinoma |
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| Zhou C,Sun J,Jin S. Telomerase activity in human primary endometrial carcinoma[J]. Chinese Journal of Oncology, 1998, 20(6): 428-430 | |
| Authors: | Zhou C Sun J Jin S |
| Abstract: | Objective To investigate the possible relationship between telomerase expression and progression of endometrial carcinoma. Methods Thirty four primary endometrial carcinoma and 6 normal endometrial tissue specimens were examined by means of telomeric repeat amplification protocol (TRAP) assay for telomerase activity. Results Of 34 endometrial cancer specimens, 28 (82.4%) showed telomerase activity, whereas 1 of 6 (16.7%) benign endometrial tissues exhibited telomerase activity. Conclusion Telomerase expression might contribute to the progression of endometrial carcinoma and could be used as its tumor marker. |
| Keywords: | Endometrial neoplasms Telomerase Polymerase chain reaction |
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