Roux-en-Y胃旁路术对非肥胖2型糖尿病患者生活质量的影响

目的观察Roux-en-Y胃旁路术（RYGB）对非肥胖2型糖尿病患者生活质量的影响。方法2008年6月至2010年10月间，前瞻性入组37例非肥胖2型糖尿病患者接受RYGB治疗，分别于术前和术后12个月，通过简明健康状况量表（SF36）、糖尿病治疗满意度问卷（DTSQ）、2型糖尿病生活质量量表（DMQLS）评价患者的生活质量。结果37例患者术后血糖和血脂均显著下降（均P〈0．05），糖尿病得到有效控制。术后12个月时，SF36生理相关综合评分（74．6±18．3）和精神相关综合评分（78．9±14．5）均高于术前（54．9±15．1和56．4±17．8，均P〈0．01）；DTSQ治疗满意度优于术前（29．2±7．1比15．4±5．6，P〈0．01）；DMQLS满意度亦优于术前（60．9±8．0比33．3±7．0，P〈0．01）。结论Roux-en-Y胃旁路术可有效地改善非肥胖2型糖尿病患者的生活质量。

Effect of Roux-en-Y gastric bypass on quality of life in non-obese patients with type 2 diabetes mellitus

Objective To observe the impact of Roux-en-Y gastric bypass on quality of life in non-obese patients with type 2 diabetes mellitus. Methods Thirty-seven non-obese patients with type 2 diabetes mellitus who underwent Roux-en-Y gastric bypass were prospectively studied. A 36-item short form healthy survey questionnaire （SF36）, the diabetes treatment satisfaction questionnaire （DTSQ）, and quality of life scale for patients with type 2 diabetes mellitus（DMQLS） were used to evaluate the quality of life for all the non-obese patients with type 2 diabetes mellitus preoperatively and 12 months postoperatively. Result The blood glucose and lipid indexes were significantly decreased after operation （all P〈0.05）. SF36 showed the physical and mental synthesis scores at 12 month after operation were 74.6±18.3 and 79.8±14.9 respectively, higher than those at one week before operation （54.9±15.1 and 56.4±17.8, both P〈0.01）. DTSQ showed treatment satisfaction score was increaced significantly after operation （29.2±7.1 vs. 15.4±5.6, P〈0.01）. The quality of life evaluated by DMQLS, was also significantly improved （P〈0.01）. Conclusion Roux-en-Y gastric bypass can significantly improve the quality of life for non-obese patients with type 2 diabetes mellitus.