加强抗菌药物使用管理前后效果的比较与分析

目的：了解加强抗菌药物使用管理后的临床使用情况，为抗菌药物的合理使用提供科学依据.方法：采用询问和查阅病历的方法，对某院2005年住院患者抗菌药物使用情况及抗菌药物费用所占总药费比例情况进行调查.结果：2005年住院患者抗菌药物总使用率为72.25%，预防性用药占48.20%，联合用药占30.54%.上半年住院患者抗菌药物使用率为80.52%，治疗性用药为41.56%，预防性用药为38.96%，联合用药占40.26%;在加强抗菌药物使用管理后，下半年抗菌药物的使用率、治疗性和预防性用药以及联合用药的比例显著地低于上半年，分别为61.14%，31.88%，29.26%和17.47%，差异有显著意义（P值均小于0.05）.下半年抗菌药物的耗资比例也低于上半年.结论：制定管理措施、加强抗菌药物使用的管理是控制抗菌药物及其合理使用的基本保证.

Survey on the antibiotics usage for inpatient and improvement of administrative countermeasures

Objectives To investigate the proper clinical utilization of antibiotics after improving the management.Methods The usage and cost of antibiotics for inpatients was surveyed in 2005 through questions and case histories.Results The rate of antibiotics usage was 72.25%,and the rate of preventive usage and combination antibiotics were 48.20% and 42.27%,respectively.After strengthening the antibiotics control,there is a striking contrast in comparison with that before antibiotic controls.The differences in the rates of antibiotics usage(80.52% vs.61.14%),antibiotic usage(41.56% vs.31.88%),preventive antibiotic usage(38.96% vs.29.26%) and combination of antibiotics usage(40.26% vs.17.47%) the in first and second half year were significant.Cost of antibiotics usage in the second half year was lower.Conclusion The key to the restrictive and rational usage of antibiotics was to make administrative countermeasures in hospital.