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| 肺癌p53基因突变检测及临床意义 | |
| 引用本文： | 王剑 高大庆. 肺癌p53基因突变检测及临床意义[J]. 肿瘤研究与临床, 2000, 12(1): 6-7 |
| 作者姓名： | 王剑 高大庆 |
| 作者单位： | 镇江市第一人民医院!江苏镇江212002 |
| 基金项目： | 镇江市科委社会发展基金!SG970 6 8 |
| 摘 要： | 目的：检测ｐ５３基因突变在肺癌组织中的表达，探讨其与临床分期与预后的关系。方法；采用银染聚合酶链反应－单链构象多态笥分析法（ＰＣＲ－ＳＳＣＰ），检测了４８例肺癌组织中ｐ５３基因突变的表达。结果：在４８例肺癌组织中，ｐ５３基因突变的检出率为４７．９％，，ｐ５３基因突变的表达与临床分期和淋巴转移有关。 |
| 关 键 词： | 肺癌 p53基因 突变 PCR－SSCP 预后 |
DETCTION OF p53 GENE MUTATION IN LUNG CANCER AND ITS CLINICAL SIGNIFICANCE |
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| WANG Jian,GAO Da qing,FU Cui mei,et al The First People''''s Hospital of Zhenjiang City. DETCTION OF p53 GENE MUTATION IN LUNG CANCER AND ITS CLINICAL SIGNIFICANCE[J]. Cancer Research and Clinic, 2000, 12(1): 6-7 | |
| Authors: | WANG Jian GAO Da qing FU Cui mei et al The First People''''s Hospital of Zhenjiang City |
| Abstract: | Objective:To investigate the expression of p53 gene mutations and to determine whether the expression was related to clinical differentiation and prognosis.Methods:48 lung tumor samples were examined by PCR SSCP to detect the expression of p53 gene mutations.Results:The expression of p53 gene mtuations was detectable in 47.9%(23/48) and was related to the clinical differetiation and lymph node mteastasis.Conclusion:The p53 gene mutation was high in lung cancer and was helpful for determing the clinical differentiation and prognosis. |
| Keywords: | Lung neoplasm p53 gene Mutation PCR SSCP Prognosis |
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