| β-纤维蛋白原-455 G/A基因多态性与脑梗死的关系 |
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| 引用本文： | 周君,李晓霞.β-纤维蛋白原-455 G/A基因多态性与脑梗死的关系[J].国外医学：物理医学与康复学分册,2006,1(3):149-150,160. |
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| 作者姓名： | 周君 李晓霞 |
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| 作者单位： | 牡丹江市第二人民医院神经内科 黑龙江牡丹江157000(周君)，牡丹江医学院预防医学教研室 黑龙江牡丹江157000(李晓霞) |
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| 摘 要： | 目的:探讨β-纤维蛋白原-455 G/A(-βFg-455G/A)基因多态性与中国东北地区汉族脑梗死发病(CI)的关系。方法:应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法,检测脑梗死组(CI组)72例和对照组69例-βFg-455G/A基因的多态性,并测定其血浆纤维蛋白原(Fg)的含量。结果:经χ2检验,各基因型频率和等位基因频率在两组间均无显著性差异(P>0.05);CI组血浆Fg水平(2.70±1.05 g/L)和对照组(2.62±0.51 g/L)比较差异无显著性意义(P>0.05)。结论:本研究未发现-βFg-455G/A基因多态性与脑梗死之间存在相关关系。
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| 关 键 词： | β-纤维蛋白原 聚合酶链反应-限制性片段长度多态性 脑梗死 |
| 文章编号： | 1001-117X（2006）03-0149-02 |
| 收稿时间： | 2006-04-24 |
| 修稿时间： | 2006-04-24 |
Association of β-Fibrinogen Gene G/A-455 Polymorphisms with Cerebral Infarction |
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| ZHOU Jun,LI Xiao-xia.Association of β-Fibrinogen Gene G/A-455 Polymorphisms with Cerebral Infarction[J].Neural Injury and Functional Reconstruction,2006,1(3):149-150,160. |
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| Authors: | ZHOU Jun LI Xiao-xia |
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| Abstract: | Objective: To investigate the relationship between β-Fibrinogen gene G/A-455 polymorphisms and cerebral infarction of Han nationality in Northeast China.Methods:β-Fibrinogen gene G/A-455 polymorphisms have been detected using PCR-RFLP technique in 72 patients with cerebral infarction(CI) and in 69 healthy controls(CON).The levels of plasma fibrinogen were determined as well.Results: No significant difference was found in frequencies of genotypes and allele between the CON group and CI group(χ~2 test,P>0.05).The plasma fibrinogen levels showed no significant difference between the two groups(2.70±(1.05 g/L) vs 2.62±0.51g/L,P>0.05).Conclusion: No close association of β-Fibrinogen gene G/A-455 polymorphisms with CI was found in this study. |
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| Keywords: | β-fibrinogen polymorphism PCR-RFLP cerebral infarction |
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