| 衰老标记蛋白-30在人晶状体上皮细胞中的表达及意义 |
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| 引用本文： | 胡美霞,罗国容,周素芳,莫发荣,谢小薰,梁皓. 衰老标记蛋白-30在人晶状体上皮细胞中的表达及意义[J]. 眼科新进展, 2008, 28(1): 13-15 |
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| 作者姓名： | 胡美霞 罗国容 周素芳 莫发荣 谢小薰 梁皓 |
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| 作者单位： | 1. 广西医科大学第一附属医院眼科,广西壮族自治区南宁市,530021
2. 广西医科大学组胚教研室,广西壮族自治区南宁市,530021 |
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| 摘 要： | 目的 研究人晶状体上皮细胞中衰老标记蛋白-30(senescence marker protein-30,SMP-30)的表达,探讨其在白内障发生发展中的作用及临床意义.方法 制备57例人晶状体前囊膜、4例正常人肝组织和2例正常人肾组织的石蜡切片.采用免疫组织化学SP法检测SMP-30在晶状体上皮细胞中的表达,并结合临床资料进行统计分析.结果 实验发现SMP-30在白内障晶状体上皮细胞的表达较透明晶状体弱(P＜0.05),其在晶状体上皮细胞的表达与性别、年龄未见相关性.结论 SMP-30在晶状体上皮细胞表达的减少可能导致白内障的发生.
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| 关 键 词： | 衰老标记蛋白-30 晶状体上皮细胞 白内障 衰老标记蛋白 人晶状体上皮细胞 细胞表达 意义 lens epithelial cells human marker senescence significance 相关性 年龄 性别 透明晶状体 发现 实验 结果 统计分析 临床资料 结合 检测 |
| 文章编号： | 1003-5141（2008）01-0013-03 |
| 收稿时间： | 2007-08-29 |
| 修稿时间： | 2007-10-17 |
Expression and significance of senescence marker protein-30 in human lens epithelial cells |
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| HU Mei-Xia,LUO Guo-Rong,ZHOU Su-Fang,MO Fa-Rong,XIE Xiao-Xun,LIANF Hao. Expression and significance of senescence marker protein-30 in human lens epithelial cells[J]. Recent Advances in Ophthalmology, 2008, 28(1): 13-15 |
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| Authors: | HU Mei-Xia LUO Guo-Rong ZHOU Su-Fang MO Fa-Rong XIE Xiao-Xun LIANF Hao |
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| Abstract: | Objective To study the expression of senescence marker protein-30(SMP-30) in human lens epithelial cells and explore its possible role and clinical significance in the emergence and development of cataract.Methods Four normal liver,two normal kidney samples and 57 human anterior lens capsule were used for detection.Immunohistochemical method was used to detect the expression of SMP-30 in lens epithelial cells.The results associated with clinical data were analyzed statistically.Results The expression of SMP-30 in transparence lens epithelial cells was higher than that in cataract lens epithelial cells(P<0.05).And it had no correlation with sex and age.Conclusion The reduction of SMP-30 expression in lens epithelial cells may result in the emergence of cataract. |
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| Keywords: | senescence marker protein-30 lens epithelial cells cataract |
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