北芪注射液治疗慢性肾炎对蛋白尿、肾功能及免疫功能的影响

56例慢性肾小球肾炎患者使用北芪注射液一疗程后:肾病组:PHA-P、IgG、IgA 明显上升,尿蛋白明显下降;肾炎组:PHA-P 明显上升,尿蛋白明显下降;肾功能不全组:PHA-P、IgM、尿蛋白明显上升,血清 Cr、BUN 明显下降。表明北芪注射液有调节细胞免疫和体液免疫、降低尿蛋白、改善肾功能的作用。本药治疗尿蛋白的有效率为61.7%。

Changes in Proteinuria,Renal Function and Immunity after Treatment with Injection of North Astragalus membranaceus

56 patients of chronic glomerulonephritis divided into nephritic,nephrotic and renal insufficiency groups were treated with injection of North Astragalus membranaceus.One course of treatment consisted of 30 injec- tions,each with 2 ml intramuscular per day.Qualitative and quantitative measurements of proteinuria,renal function test,non specific cellular immunity PHA-pereutaneous(PHA-P)test,PHA induced lymphocyte trans- formation H 3 test(PHA-Tr),adenosine induced suppression assay(AISA),serum lgG,IgA,IgM,C3,C4, CH 50,ACH 50(factor B),CIC:PEG precipitating assay,C 1 q-ELISA,Clq binding assay,proteinuria in 24 h.,Cr, BUN were measured before and after treatment. Before treatment,PHA-P was evidently lower than normal controls,IgG and IgA were lower,and IgM was higher than normal in-nephrotic group.In uremia IgG,IgA and IgM were all lower than normal.C 3 decreased in 36/56,factor B was reduced in 13 correlatively with C 3.CIC positive in Clq ELISA,C lq BA and PEG-PA was 40.4%,40.8% and 32.1% respectively. After treatment,PHA-P increased,CIC tended to decrease but without statistical significance,and IgG and IgA increased in nephrotie group after 1 course.Increase in renal insufficiency group was found after 3 courses of treatment.The complement system improved but without statistical significance.Proteinuria decreased in nephritic and nephrotic groups;increase in the uremic group was parallel to improvement of the renal function, and decrease was found with successive treatment after 50 injections.The total effective rate was 61.7%. Based on the above observation,injection of North Astragalus membranaceus can improve cell-mediated and humoral immunity,reduce proteinuria and improve the renal function.It has certain effects in the treatment of glomerulonephritis patients.