通心络胶囊联合静脉溶栓对急性心肌梗死的临床研究

目的:观察通心络胶囊联合静脉溶栓治疗急性心肌梗死(AMI)的疗效观察及其对心肌微循环再灌注影响。方法:将我院2010-01～2012-12间31例急性心肌梗死患者随机分为通心络胶囊组(A组)16例与对照组(B组)15例。A组在药物溶栓治疗(尿激酶/链激酶+硝酸酯类药物+低分子量肝素钙+血管紧张素转换酶抑制剂+β受体阻滞剂+阿司匹林肠溶片)基础上加用通心络胶囊,首剂6粒,以后常规2粒/次,3次/天口服,疗程15d;B组按常规溶栓治疗方案治疗。观察A、B两组开始溶栓后心电图ST段回落情况、心肌酶谱指标、并发症及60d后EF值测定,并对上述数据进行统计学处理(计量资料以x-±s表示,组间比较采用t检验,记数资料以百分率表示,组间比较用x2检验,P<0.05为显著性差异)。结果:A组与B组相比,A组有效率、心电图ST段回落情况、EF值大于B组,A组并发症小于B组,A组酶峰前移并明显下降。结论:通心络胶囊联合静脉药物溶栓对急性心肌梗死(AMI)患者的治疗效果肯定,对溶栓后的心肌再灌注的改善有明确的临床效果。

CLINICAL STUDY OF TONGXINLUO CAPSULE COMBINED WITH INTRAVENOUS THROMBOLYSIS FOR ACUTE MYOCARDIAL INFARCTION

Objective：To observe the therapeutic effect of Tongxinluo capsule combined with intravenous thrombolysis in treatment of acute myocardial infarction （AMI） and the effect of reperfusion of myocardial microcirculation. Methods：31 patients with acute myo- cardial infarction in our hospital from 2010 January to December were randomly divided into Tongxinlro capsule group （ group A） 16 ca- ses and control group （group B） 15 cases. On the basis of thrombolytic drugs （Urokinase / Streptokinase ＋ Drugs belonging to ester nitrate ＋ Low molecular weight heparin calcium ＋ Angiotension converting enzyme inhibitor ＋ Beta blockers ＋ Aspirin enteric - coated tablets ）, Group A combined with Tongxinluo capsule, the starting dose is 6, after conventional dosage 2 tablets were given each time. Orally, three times daily, treatment asted for 15 days. Group B treated in conventional thrombolytic therapy program. Ob- servation of the two groups A and B about ST - segment resolution situation in electrocardiogram after thrombolysis, myocardial enzyme spectrum index, complications and numerical determination of EF after 60 days, and these data were analyzed with statistical treatment （measurement data were expressed asx ＋ s. T - test was used for the group comparison. Count data were expressed in percentage. Groups were compared with x2 - test, significant difference was p 〈 0. 05. ） Results： compared with group A and B, Group A is more efficient. ST - segment resolution situation in electrocardiogram and EF was more than group B, and complications were less than group B. The enzyme peak of Group A moved forward and decreased obviously. Conclusion：Tongxinluo capsule combined with intravenous thrombolysis for acute myocardial infarction （AMI） patients is positive in clinical effect. It has exact clinical significance for reperfu- sion of myocardial microcirculation after thrombolysis.