血清同型半胱氨酸和超敏C-反应蛋白与冠心病相关性研究

目的探讨冠心病（CHD）患者血清中同型半胱氨酸（Hcy）和超敏C-反应蛋白（hs-CRP）水平的变化,为CHD的诊治和预防提供可靠依据。方法将85例CHD患者分为3组：急性心肌梗死（AMI,n=30）组,不稳定性心绞痛（UAP,n=28）组,稳定性心绞痛（SAP,n=27）组,同时选择40例健康体检人群作为健康对照组,检测血清中Hcy和hs-CRP含量。结果 （1）CHD组Hcy与hs-CRP含量均显著高于健康对照组,差异有统计学意义（P〈0.01）;（2）CHD各组之间血清Hcy和hs-CRP含量亦存在显著差异,AMI组大于UAP组大于SAP组。结论 Hcy与hs-CRP是CHD的危险因子,血清中Hcy和hs-CRP含量与CHD之间关系密切,二者联合检测有助于对CHD患者的诊断和防治,同时也与疾病的严重程度密切相关。

The correlation between the levels of homocysteic acid and high-sensitivity C-reactive protein in serum and coronary heart disease

Objective To investigate the changes of levels of homocysteic acid（Hcy） and high-sensitivity C-reactive protein（hs-CRP） in serum in patients with coronary heart disease（CHD）,provide a reliable basis for the diagnosis,treatment and prevention of CHD.Methods 85 patients with CHD were divided into 3 groups,acute myocardial infarction group（n=30）,unstable angina pectoris group（n=28）,stable angina pectoris group（n=27）,40 healthy persons as a healthy control group.The levels of Hcy and hs-CRP in serum were detected.Results ① The levels of HCY and hs-CRP were significantly higher in CHD than those in healthy control（P0.01）.②The levels of Hcy and hs-CRP also have the significant difference between three groups,AMI groupUAP groupSAP group.Conclusion Hcy and hs-CRP are the risk factors for CHD.There has the close relationship between the expression of Hcy and hs-CRP in serum and CHD.Combination of the two tests provide a reliable basis for the diagnosis,treatment and prevention of CHD and also closely related with the severity of the disease.