中国妇女宫颈癌行为危险因素的Meta分析

目的 探讨中国妇女宫颈癌发病的行为危险因素.方法 应用Revman 5.0对国内已发表的33篇有关宫颈癌的病例对照研究进行定量综合分析.结果 各因素合并OR值（95％CI）分别为：性交年龄3.33（2.57 ～ 4.31）,怀孕年龄2.00（1.28 ～ 3.12）,生育年龄1.57（1.01 ～ 2.45）,怀孕次数2.37（1.87 ～ 3.00）,流产次数2.98（1.96 ～4.53）,生育次数2.79（2.26～3.44）,性伴侣数3.38（2.33 ～4.90）,结婚次数2.98（1.68 ～ 5.27）,应用避孕套0.32（0.20 ～ 0.49）,无任何避孕措施2.16（1.07 ～4.34）,性生活前清洗阴道0.55（0.34～0.87）,吸烟2.50（1.74～3.59）,被动吸烟史2.84（1.84 ～ 4.39）,喝茶0.36（0.27 ～ 0.50）及从事脑力劳动0.35（0.17 ～ 0.72）.结论 首次性交、怀孕、生育年龄过早、怀孕、流产、生育、结婚次数、性伴侣数过多、无任何避孕措施及吸烟和被动吸烟是宫颈癌发病的行为危险因素;应用避孕套、性生活前清洗阴道、喝茶和从事脑力劳动是宫颈癌发病的行为保护因素.

Meta-analysis on the Behavioral Risk Factors of Cervical Cancer in Chinese Women

OBJECTIVE To investigate of the behavioral risk factors of cervical cancer in Chinese women. METHODS Thirty-three re- cently published case control studies associated with cervical cancer were quantitative analyzed in Revman 5.0. RESULTS Pooled odds ratios OR（95% CI） for all behavioral factors were as following： age at first sexual intercourse were 3.33（2.57- 4.31）, age at first pregnancy were 2.00（1.28 - 3.12）, age at first childbearing 1.57（1.01 - 2.45）, number of pregnancies were 2.37（1.87 - 3.00）, number of abortions were 2.98（1.96 - 4.53）, number of births 2.79（2.26 - 3.44）, number of sexual partners were 3.38（2.33- 4.90）, number of married times 2.98（1.68 to 5.27）, application of condoms 0.32（0.20 to 0.49）, without any contraceptive measures were 2.16（1.07 - 4.34）, cleaning the vagina before sexual were 0.55（0.34 - 0.87）, smoking were 2.50（1.74 - 3.59）, passive smoking histo- ry were 2.84（1.84 - 4.39）, tea 0.36（0.27 - 0.50） and engaged in mental were 0.35（0.17 - 0.72）. CONCLUSION Early age at first sexual intercourse, pregnancy, childbearing, large number of pregnancies, abortions, births, sexual partners, married times, without any contraceptive measures, smoking, passive smoking history, are the behavioral risk factors of cervical cancer; application of condoms, cleaning the vagina before sexual, tea, engaged in mental are the protective factors for cervical cancer.