硝苯地平对妊娠高血压综合征患者产后出血的影响

目的　观察产时使用硝苯地平对妊娠高血压综合征 (妊高征 )患者产后出血的影响。方法　 6 4例妊高征患者分为硝苯地平组和对照组各 32例 ,两组患者均口服硝苯地平 10～ 2 0mg ,每日 3次。对照组在出现规律宫缩后停止使用 ;硝苯地平组继续以每 6h 1次服用硝苯地平 10～ 2 0mg ,直至第二产程末 ,观察两组患者产后 2h内出血量。结果　 (1)产后 2h内出血量 ,硝苯地平组为 (35 9.1±136 .6 )ml,对照组为 (2 6 8.5± 110 .7)ml,两组比较 ,差异有极显著性 (P <0 .0 1)。 (2 )两组妇女产后出血百分比显示 ,硝苯地平组为 43.75 % (14/ 32 ) ,对照组为 18.75 % (6 / 32 ) ,两组比较 ,差异有显著性 (P <0 .0 5 )。结论　妊高征患者产时应用硝苯地平会增加产后出血量 ,易引起产后出血。

The Effect of Nifedipine on Postpartum Blood Loss in Patients with Pregnancy Induced Hypertension

OBJECTIVE: To determine the efficacy of Nifedipine on postpartum blood Loss in patients with Pregnancy Induced Hypertension (PIH). METHODS: 64 cases of PIH were randomly divided into study group (n = 32) and control group (n = 32). Before labor Nifedipine 10 mg-20 mg was given three time daily for all cases. In study group Nifedipine was taken orally every 6 hours during the labor course until the end of second stage. In control group Nifedipine was not given in the labor stages. The postpartum blood loss was collected and measured carefully within 2 hours after delivery. RESULTS: The amount of pastpartum hemorrhage was (359.1 +/- 136.6) ml in study group which was significantly higher than that of control group (268.5 +/- 110.7) ml P < 0.01. The postpartum hemorrhage rate in study and control group was 43.75% and 18.75% respectively. The difference was statistically significant (P < 0.05). CONCLUSION: During labor using Nifedipine for PIH cases can increase the amount of postpartum blood loss and rate of postpartum hemorrnage.