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| 间充质干细胞外泌体治疗脊髓损伤作用机制的研究进展 | |
| 引用本文： | 陈武,蓝常贡,罗宏成. 间充质干细胞外泌体治疗脊髓损伤作用机制的研究进展[J]. 中华创伤杂志, 2021, 0(2): 171-175 |
| 作者姓名： | 陈武 蓝常贡 罗宏成 |
| 作者单位： | 右江民族医学院研究生学院;右江民族医学院附属医院脊柱外科;右江民族医学院附属医院检验科 |
| 基金项目： | 国家自然科学基金(81660369);广西自然科学基金(2016GXNSFAA380173);广西卫生计生委项目(Z2016411);广西科技计划项目(2019JJB140023)。 |
| 摘 要： | 脊髓损伤后继发性损伤及胶质瘢痕,使神经细胞在微环境中出现再生障碍,导致治疗困难.间充质干细胞(MSCs)具有多向分化、自我更新能力、参与免疫调节等功能,可用于治疗脊髓损伤,但存在不易通过血脊屏障、高致瘤性等缺点.MSCs外泌体是由MSCs分泌的纳米级外囊泡,包裹多种活性物质,在脊髓损伤研究中具有极强的神经修复作用,且具... |
| 关 键 词： | 脊髓损伤 外泌体 间充质干细胞 |
Research progress in mechanism of mesenchymal stem cells-derived exosomes treating spinal cord injury |
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| Chen Wu,Lan Changgong,Luo Hongcheng. Research progress in mechanism of mesenchymal stem cells-derived exosomes treating spinal cord injury[J]. Chinese Journal of Traumatology, 2021, 0(2): 171-175 | |
| Authors: | Chen Wu Lan Changgong Luo Hongcheng |
| Affiliation: | (Graduate School,Youjiang Medical University for Nationalities,Baise 533000,China;Department of Spine and Orthopedics,Affiliated Hospital of Youjiang Medical University for Nationalities,Baise 533000,China;Department of Laboratory Medicine,.Affiliated Hospital of Youjiang Medical Unii'ersity for Nationalities,Baise 533000,China) |
| Abstract: | Secondary injury and the glial scar after spinal cord injury can adversely affect nerve regeneration in the microenvironment,leading to treatment difficulties.Mesenchymal stem cells(MSCs)have multi-differentiation,self-renewal ability,participation in immune regulation and other functions and can be used to treat spinal cord injury,but they are not easy to pass the blood spine barrier and have high tumorigenicity and other disadvantages.MSCs-derived exosomes are nanometer exosomes secreted by MSCs,which contain many active substances.These exosomes have a strong neurorepair effect in spinal cord injury research,and have advantages of easy penetration,stability and low tumorigenicity,etc.These exosomes make up for the disadvantages of MSCs treatment,and are expected to replace MSCs in treatment of spinal cord injury.The authors review the biological characteristics of MSCs-derived exosomes and its mechanism in the treatment of spiiuil cord injury,so as to provide references for the treatment of spinal cord injun. |
| Keywords: | Spinal cord injuries Exosomes Mesenchymal stem cells |
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