Effect of choice of outcome measure on studies of the etiology of obesity in children |
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| Authors: | Laura Basterfield Mark S. Pearce Ashley J. Adamson Jessica K. Reilly Kathryn N. Parkinson John J. Reilly |
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| Affiliation: | 1. Institute of Health and Society, Human Nutrition Research Centre, Newcastle University, Newcastle upon Tyne, UK;2. Physical Activity for Health Research Group, School of Psychological Science and Health, University of Strathclyde, Jordanhill Campus, Glasgow, Scotland;3. Institute of Health and Society, Newcastle University, Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne, UK;1. Laboratory of Chemical Neuroanatomy, Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo – USP, 05508-000, São Paulo, Brazil;3. Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, UNIFESP, 04023-062, São Paulo, Brazil;4. Department of Physiology, Institute of Biosciences, University of São Paulo – USP, 05508-090, São Paulo, Brazil;5. Laboratory of Functional Neuroanatomy, Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo - USP, 05508-000, São Paulo, Brazil;6. Center for Neuroscience and Behavior, Institute of Psychology, University of Sao Paulo – USP, 05508-900, São Paulo, Brazil;1. Department of Chemistry, Tarbiat Modares University, P.O. Box 14115-175, Tehran, Iran;2. Department of Analytical Chemistry, Faculty of Chemistry, K.N. Toosi University of Technology, Tehran, Iran;1. Department of Process and Chemical Engineering, University College Cork, Ireland;2. MACSI, Department of Mathematics and Statistics, University of Limerick, Ireland;3. Department of Physics, University College Cork, Ireland;1. Centre for Sport Research, School of Exercise and Nutrition Sciences, Deakin University, Australia;2. College of Sport and Exercise Science, Victoria University, Australia;1. Fibrous Materials Research Group, University of Minho, 4800-058 Guimarães, Portugal;2. Department of Civil Engineering, University of Minho, 4800-058 Guimarães, Portugal |
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| Abstract: | ![]()
PurposeEpidemiologic studies of the etiology of childhood obesity often use proxies for adiposity as outcomes. This study aimed to compare the ability of a range of proxy measures to detect associations with sedentary behavior.MethodsLongitudinal study of children in the Gateshead Millennium Study who were 7 years at baseline and 9 years at follow-up. Associations between 2-year changes in objectively measured sedentary behavior and changes in proxies for adiposity (waist circumference, waist Z score, body mass index, body mass index Z score) and measurement of body composition (fat mass index from bioelectric impedance) were examined. Associations were tested with linear regression.ResultsAssociations between 2-year increases in sedentary behavior and increases in adiposity were detectable by using the fat mass index as the outcome, but not the simple proxy measures of adiposity, as outcomes.ConclusionsProxy measures are inferior to measures of body composition as outcomes in epidemiologic studies. |
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