Alzheimer's disease in a patient on long-term hemodialysis: a case report |
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| Authors: | B Trappler R Viswanathan J Sher |
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| Affiliation: | 1. Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China;2. Department of Clinical Laboratory, Affiliated Hospital of Military Medical Science Academy of PLA, 8 East street, Beijing 100071, China;3. The Third Outpatient Department of the General Logistics Department, Beijing 10039, China;1. Professor, Division of Renal Diseases and Hypertension, Department of Medicine, George Washington University, Washington, DC, United States;2. Assistant Professor, Division of Renal Diseases and Hypertension, Department of Medicine, George Washington University, Washington, DC, United States;1. Second Affiliated Hospital of Xinjiang Medical University, Urumqi 830028, China;2. The PLA Psychiatry Center, The 102nd Hospitial of PLA, Changzhou 213003, China;3. The Affiliated Wenling Hospital of Wenzhou Medical University, Wenling 317500, China;4. College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China;5. Beijing Hui-Long-Guan Hospital, Peking University, Beijing 100096, China;6. Psychosomatic Medicine Research Division, Inner Mongolia Medical University, Huhhot 010110, China;1. Department of Health Sciences Research, Mayo Clinic, Rochester, MN;2. Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA;3. Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN;4. Corner Home Medical, New Hope, MN |
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| Abstract: | ![]()
This case report describes a progressive dementia in a 49-year-old black male on long-term hemodialysis. The initial presentation simulated depression. The dementia persisted after an unsuccessful cadaver homograft transplant. The character of the dementia was nonspecific but typical features of dialysis dementia were lacking. Autopsy revealed a ruptured cerebral aneurysm, polycystic kidneys, moderately severe atherosclerosis, miliary tuberculosis, and neurofibrillary degeneration of the hippocampus. The significance of a possible relationship between end-stage renal disease (ESRD), hemodialysis, and Alzheimer's disease in this case is discussed. |
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