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Inducible nitric oxide synthase inhibitors fromMelia azedarach var.Japonica |
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| Authors: | Hak Cheol Kwon Byeong Gon Lee Seung Hee Kim Chil Mann Jung Sung Youl Hong Jeung Whan Han Hyang Woo Lee Ok Pyo Zee Kang Ro Lee |
| Affiliation: | College of Pharmacy, Sung Kyun Kwan University, Suwon, Korea. |
| Abstract: | In bioassay-guided search for inducible nitric oxide synthase (iNOS) inhibitory compounds from higher plants of South Korea, two beta-carboline alkaloids, 4-methoxy-1-vinyl-beta-carboline (1) and 4,8-dimethoxy-l-vinyl-beta-carboline (2) have been isolated from the cortex of Melia azedarach var. japonica. The structures of these compounds were elucidated on the basis of spectroscopic data. Compounds 1 and 2 showed marked inhibitory activity of iNOS on LPS- and interferon-gamma-stimulated RAW 264.7 cells. |
| Keywords: | Melia azedarach var.japonica 4-Methoxy-1-vinyl-carboline 4,8-Dimethoxy-1-vinyl-β -carboline Inducible nitric oxide synthase |
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