| p53、bcl-2蛋白在成釉细胞瘤中表达的研究 |
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| 引用本文： | 战德松,于学垠,钟鸣. p53、bcl-2蛋白在成釉细胞瘤中表达的研究[J]. 中国血液流变学杂志, 2005, 15(2): 222-224 |
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| 作者姓名： | 战德松 于学垠 钟鸣 |
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| 作者单位： | 中国医科大学口腔医学院,辽宁沈阳,110002 |
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| 摘 要： | 目的探讨成釉细胞瘤中p53、bcl-2蛋白表达的生物学意义。方法采用免疫组化S-P法检测成釉细胞瘤中p53蛋白及bcl-2蛋白。结果成釉细胞瘤及正常口腔粘膜中,p53蛋白表达阳性率为85.3%和33.3%,组间差异显著(P<0.01)。bcl-2蛋白表达阳性率为88%、44.4%,组间差异显著(P<0.001)。p53蛋白表达与bcl-2蛋白表达呈正相关(P<0.01)。结论1)p53蛋白表达是判断成釉细胞瘤预后的指标。2)bcl-2蛋白与p53蛋白在成釉细胞瘤中协同发挥作用。
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| 关 键 词： | 成釉细胞瘤 免疫组化 p53蛋白:bcl-2蛋白 |
| 文章编号： | 1009-881X(2005)02-0222-03 |
| 收稿时间： | 2005-02-07 |
| 修稿时间： | 2005-02-07 |
Expression of p53 Protein and bcl-2 Protein in Ameloblastoma |
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| ZHAN De-song,YU Xue-Yin,ZHONG Ming. Expression of p53 Protein and bcl-2 Protein in Ameloblastoma[J]. Chinese Journal of Hemorheology, 2005, 15(2): 222-224 |
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| Authors: | ZHAN De-song YU Xue-Yin ZHONG Ming |
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| Affiliation: | College of Stomatology ,China Medical University ,Shenyang 110002 |
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| Abstract: | Objective Our aim was to study the expression of p53 protein and bcl-2 protein in amleoblastoma and investigate biological behaviour of AB.Methods The p53 protein and bcl-2 protein were determined with S-P method.Results The positive rates of p53 protein in AB and normal oral mucosa were 85.3% and 33.3%.There were statistical differences among groups (P<0.01).bcl-2 protein was 88% and 44.4%(P<0.001).There was a positive correlation between p53 and bcl-2 in AB (P<0.01).Conclusion 1)The expressions of p53 protein are important signs to evaluate the prognosis of AB.2)bcl-2 plays an important role in AB cooperate with p53. |
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| Keywords: | ameloblastoma immuno-histochemistry p53 protein bcl-2 protein |
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