冠心病患者Ab-ox-LDL及C反应蛋白升高的意义

目的 探讨血清氧化低密度脂蛋白自身抗体（Ab—ox—LDL）及高敏C反应蛋白（hs—CRP）水平与冠心病的关系。方法 将105名患者分为对照组、稳定型心绞痛组、不稳定型心绞痛组和急性心肌梗死组，采用ELISA法测定血清Ab—ox—LDL和hs—CRP浓度。结果 冠心病各组血清Ab—ox—LDL及hs—CRP水平明显高于对照组（P〈0．01），急性心肌梗死组和不稳定性心绞痛组高于稳定型心绞痛组，急性心肌梗死组高于不稳定性心绞痛组；Ab—ox—LDL和hs—CRP在对照组呈低度正相关，在冠心病组呈高度正相关；在冠心病组，Ab—ox—LDL与Gensini积分呈低度相关。结论 血清Ab—ox—LDL及hs—CRP水平可反映冠心病患者病变的程度，评价冠心病斑块的稳定性，二者在冠状动脉硬化进程中起着重要的作用。

Significance of the Increase in Levels of Serum Autoantibody Against Oxidized Low Density Lipoprotein and C Reactive Protein in Patients with Coronary Artery Disease

Objective To investigate the relationship of antibody against oxidized low density lipoprotein (Ab-ox-LDL) and high-sensitivity C-reactive protein (hs-CRP) with the plaque stability in coronary artery disease (CAD). Methods Serum Ab-ox-LDL and hs-CRP was measured by enzyme-linked immunosorbent assay in 105 patients who were divided into 4 groups, stable angina pectoris (SAP), unstable angina pectoris (UAP), acute myocardial infarction (AMI) and control. Results The levels of Ab-ox-LDL and hs-CRP in all CAD groups were higher than control group, higher in AMI and UAP groups than in SAP group, and higher in AMI group than UAP group. There was significantly positive correlation between Ab-ox-LDL and hs-CRP in patients with CAD, but low correlation in the control. There was low correlation between Ab-ox-LDL and Gensini' integral in patients with CAD. Conclusions Serum Ab-ox-LDL and hs-CRP can predict a presence of atherosclerotic CAD, and may mark the plaque instability. Ab-ox-LDL and hs-CRP play an important role in the development of atherosclerosis.