畸变产物耳声发射检测结果与耳鸣疗效的相关性分析

目的 探讨畸变产物耳声发射(DPOAE)检测结果与耳鸣疗效的相关性.方法 选取出现DPOAE异常的耳鸣患者92例,按DPOAE异常频率与耳鸣主调是否匹配及病程长短进行分组,92例患者全部给予银杏叶提取物、甲钴胺、维生素B1等药物治疗,2周后对比组间的治疗效果.结果 DPOAE对应组的治疗有效率明显高于非对应组(P<0.01),短病程组的治疗有效率明显高于长病程组(P<0.01).结论 DPOAE检测可以早期发现耳蜗的轻微损伤,对于耳鸣患者的病情评估及疗效预判具有重要意义.

An Analysis of the Relationship between Distortion Product Otoacoustic Emissions and Tinnitus Treatment Outcome

Objective To investigate the relationship between distortion product otoacoustic emissions（DPOAE） and tinnitus treatment outcome. Methods Ninety-two tinnitus patients were divided into two groups according, to the relationships between abnormal DPOAE frequencies and main tinnitus frequencies and also the durations of tinnitus. All the 92 cases were treated with medicine, such as ginkgo biloba leaf extract, vitamine B1 and mecobalamin. After two weeks of treatment, the efficacy of the medicine was observed and compared between the different groups. Results The effective rate of DPOAE-related tinnitus group was significantly higher than non-related group （P〈0.01）. The effective rate of short-lasting tinnitus group was higher than that of long-lasting group（P〈0.01）. Conclusion DPOAE may be helpful in detecting the minimal injury in cochleae early, which is of great importance to the evaluation of tinnitus and to the prediction of treatment outcome.