Balloon pulmonary angioplasty attenuates sleep apnea in patients with chronic thromboembolic pulmonary hypertension |
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| Affiliation: | 1. Department of Intensive Care Medicine, Gelderse Vallei Hospital, Willy Brandtlaan 10, 6716, Ede, the Netherlands;2. Department of Intensive Care Medicine, Head of ICU, Gelderse Vallei Hospital, Willy Brandtlaan 10, 6716 RP, Ede, the Netherlands;1. Department of Cardiology, Institute for Clinical and Experimental Medicine, Videnska 1958/9, 140 21, Prague, Czech Republic;2. Third Faculty of Medicine, Charles University, Prague, Czech Republic;1. Hacettepe University, Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation, Ankara, Turkey;2. Hacettepe University, Faculty of Medicine, Department of Chest Diseases, Ankara, Turkey;1. Department of Psychology, Ohio State University, Columbus, OH, USA;2. Department of Internal Medicine, Ohio State University, Columbus, OH, USA;3. Department of Pediatrics, Ohio State University, Columbus, OH, USA;4. Institute for Behavioral Medicine Research, Ohio State University, Columbus, OH, USA;5. Center for Biobehavioral Health, Nationwide Children''s Hospital, 700 Children''s Drive, Columbus, OH 43205, USA |
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| Abstract: | ![]()
BackgroundBalloon pulmonary angioplasty (BPA) improves pulmonary hemodynamics in chronic thromboembolic pulmonary hypertension (CTEPH) patients. However, whether it affects the severity of sleep apnea (SA) remains unknown. We investigated the effect of BPA on the severity of SA in CTEPH patients.MethodsWe studied 13 patients with CTEPH who had an apnea hypopnea index (AHI) > 10 before BPA and underwent a second polygraph test 6 months after the last BPA session.ResultsBPA decreased pulmonary vascular resistance, mean pulmonary artery pressure (PAP), and plasma B-type natriuretic peptide levels, and increased the 6-minute walking distance. BPA decreased the AHI (from 20.9 [13.9–35.7] to 16.3 [7.7–21.8] times/hour, P = 0.023) and hypopnea index (from 13.2 [8.4–22.5] to 6.4 [3.8–10.9] times/hour, P = 0.013), but not the obstructive, central, or mixed apnea index. The change in AHI correlated with that in mean PAP, but not with the change in body mass index or other parameters of hemodynamics.ConclusionsBPA-induced improvement in hemodynamics was associated with the attenuation of SA in patients with CTEPH and SA. Therefore, close attention should be paid to SA in CTEPH patients, and SA should be re-evaluated after BPA to avoid overestimating its severity. |
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