定坤丹治疗子宫内膜薄型不孕的临床效果

目的 观察定坤丹治疗子宫内膜薄型不孕的临床效果,为优化子宫内膜薄型不孕的治疗方案提供参考。方法 选取187例子宫内膜薄型不孕患者,在保证组间基本特征匹配原则上,利用计算机软件产生的随机数,按照1∶1的比例分为对照组(93例)和观察组(94例)。对照组给予雌二醇+地屈孕酮干预,观察组在对照组的基础上加用定坤丹。比较治疗3个周期后两组患者的子宫内膜厚度、孕激素浓度及临床妊娠率。结果 观察组患者排卵期平均子宫内膜厚度显著高于对照组(P<0.01),黄体期孕激素浓度显著高于对照组(P<0.01),累计临床妊娠率显著高于对照组(P<0.05)。结论 定坤丹可以明显改善子宫内膜薄型不孕患者排卵期子宫内膜厚度,提高黄体功能,改善妊娠结局。

Clinical effects of Dingkun pill on thin endometrium infertility

Objective To optimize the treatment methods of thin endometrial infertility and provide more effective clinical options. Methods A total of 197 patients with thin endometrium infertility were randomly assigned to the control group and the experimental group. The endometrial thickness, progesterone level and clinical pregnancy rate between the two groups were compared to each other. The control group was treated with estradiol + dydrogesterone, while the experimental group was treated with Dingkun pill in addition to the treatment in the control group. Results Compared to that in the control group, the average endometrial thickness during ovulation (P<0.01),the progesterone level in luteal phase (P<0.01) ,and the cumulative clinical pregnancy rate was significantly higher (P<0.05) in the experimental group. Conclusion Dingkun pill could significantly improve the endometrial thickness, luteal function and pregnancy outcome in thin endometrial infertility.