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Opium tincture versus methadone for opioid agonist treatment: a randomized controlled trial
Authors:Mohammadali Nikoo  Kiana Kianpoor  Nooshin Nikoo  Sanam Javidanbardan  Alireza Kazemi  Fiona Choi  Marc Vogel  Ali Gholami  Saeed Tavakoli  James S. H. Wong  Ehsan Moazen-Zadeh  Reza Givaki  Majid Jazani  Fatemeh Mohammadian  Nader Markazi Moghaddam  Christian Schütz  Kerry Jang  Shahin Akhondzadeh  Michael Krausz
Affiliation:1. Institute of Mental Health, Department of Psychiatry, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada;2. Institute of Mental Health, Department of Psychiatry, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada

Contribution: Data curation (supporting), Formal analysis (supporting), Methodology (supporting), Software (supporting);3. Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada

Contribution: Conceptualization (supporting), Methodology (supporting);4. Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada

Contribution: Methodology (supporting), Project administration (equal);5. Institute of Mental Health, Department of Psychiatry, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada

Contribution: Funding acquisition (supporting), Project administration (supporting), Software (lead);6. Division of Substance Use Disorders, Psychiatric Services of Thurgovia, Münsterlingen, Switzerland;7. Kian Methadone Maintenance Treatment Clinic, Private Practice, Sari, Mazandaran, Iran;8. Rooz-e-No, Methadone Maintenance Treatment Clinic (Private Practice), Shiraz, Fars, Iran;9. Addiction Institute of Mount Sinai, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, NY, USA;10. Psychosomatic Research Center, Isfahan University of Medical Sciences, Isfahan, Iran;11. Sales, Marketing, Export and Medical Department, Darou Pakhsh Pharmaceutical Manufacturing Company, Tehran, Iran;12. Department of Health Management and Economics, School of Medicine, AJA University of Medical Sciences, Tehran, Iran

Contribution: Funding acquisition (supporting), Methodology (supporting);13. Institute of Mental Health, Department of Psychiatry, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada

Contribution: Conceptualization (supporting), Methodology (supporting), Supervision (supporting);14. Psychiatric Research Center, Roozbeh Hospital, Department of Psychiatry, Faculty of Medicine, Tehran University of Medical Sciences, Iran

Contribution: Conceptualization (equal), Funding acquisition (lead), Methodology (equal), Supervision (equal);15. Institute of Mental Health, Centre for Health Evaluation and Outcome Sciences, Department of Psychiatry, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada

Contribution: Conceptualization (equal), Funding acquisition (supporting), Methodology (equal), Supervision (equal)

Abstract:
Keywords:Clinical trial  methadone  opioid agonist treatment  opioid substitution treatment  opium  opium tincture  retention
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