抵抗素、脂联素浓度与高血压病血瘀证关系的研究

目的比较高血压病血瘀证与非血瘀证患者抵抗素、脂联素等差异,探讨高血压病患者脂肪因子与血瘀证的关系。方法空腹取静脉血制备血浆、血清,酶免检测血清脂联素、抵抗素,放免检测血清瘦素、胰岛素和血浆内皮素、肿瘤坏死因子,酶法检测空腹血清血糖、总胆固醇、三酰甘油、高密度脂蛋白胆固醇及低密度脂蛋白胆固醇浓度。结果血瘀证检出率为25%。与非血瘀证组相比,血瘀证组瘦素、内皮素浓度升高（P〈0.05）,脂联素水平降低（P〈0.05）;抵抗素、胰岛素、肿瘤坏死因子水平差异无统计学意义（P〉0.05）;抵抗素、脂联素二者与瘦素、胰岛素、内皮素均未见明显相关关系（P〉0.05）。胰岛素与瘦素呈正相关（r=0.714 2,P〈0.01）。结论肥胖与血瘀证相关;瘦素与血瘀证的联系可能是通过调节血管活性因子水平实现的,脂联素具有防止血瘀证形成的作用;高血压病肥胖者血瘀证的形成可能与抵抗素无关。

Correlation between Resistin,Adiponectine and Blood Stasis Syndrome in Hypertension

Objective By analyzing and comparing the content of resistin,adiponectine,leptin,insulin,glucolipid metabolism,endothelin（ET） in primary hypertension patients（pts） with and without blood stasis syndrome,to approach the mechanism of blood stasis syndrome in hypertension.Methods Fifty-seven pts were divided into blood stasis syndrome group and non-blood stasis syndrome group.Serum adiponectine and resistin were checked by enzyme linked immunosorbent assay（ELISA）.The serum insulin,leptin,ET and tumor necrosis factor（TNF） were detected by radioimmunoassay.The fasting blood sugar,total cholesterol,triamid-glycerin,high dense lipoprotein-cholesterol and low dense lipoprotein-cholesterol were detected.Results The detectable rate of the blood stasis syndrome group was 25 percent.Compared with the non-blood stasis syndrome group,the levels of leptin and ET in blood stasis syndrome group were raised significantly,but the adiponectine was decreased（P0.05）.There were no different significantly in resistin,tumor necrosis factor-alpha（TNF-α）and insulin（P0.05）.There was positive correlation between insulin and leptin（r=0.714 2,P0.01）.Conclusion There was positive correlationship between obesity and the blood stasis syndrome.Adiponectine could prevent blood statsis syndrome.There was no relation between obesity and resistin.